TFMPP (piperazine) basics

Discussion in 'Piperazines' started by Alfa, Nov 12, 2005.

  1. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    Please post information about TFMPP here. TFMPPhas been banned in Japan.
     
  2. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    Serotonin receptors and animal models of aggressive behavior.

    Olivier B, Mos J, van Oorschot R, Hen R.

    CNS-Pharmacology, Solvay Duphar B.V., Weesp, The Netherlands.

    Various models of rodent agonistic behavior are described, which differentiate between offensive and defensive/flight models. Particular attention is given to one male and one female paradigm for offensive aggression, i.e. resident/intruder or territorial aggression (RI) and maternal aggression (MA). After an overview of the serotonin (5-HT) system in the CNS, a description is given of the ligands available. Subsequently, the effects of various drugs affecting serotonergic transmission in the RI- and MA-paradigms are described. The 5-HT1A receptor agonists busipirone, ipsapirone, and 8-OH-DPAT decreased aggression in RI and MA, but simultaneously led to a marked decrease in social interest and activity, indicative of a nonspecific antiaggressive profile. Nonselective 5-HT1 receptor agonists, such as RU24969, eltoprazine, and TFMPP reduced aggression quite specifically, did not decrease social interest or exploration, and sometimes even increased these behaviors. In RI and MA, the behavioral effects of these drugs were roughly similar. In contrast, MA was more sensitive to treatment with the 5-HT reuptake blocker fluvoxamine, which blocked RI aggression nonspecifically at the highest dose only. DOI, a 5-HT2A/2C# receptor agonist, decreased aggressive behavior and increased inactivity, without affecting social interest and exploration in RI as well as MA. This was, however, accompanied by "wet dog shaking" characteristic of 5-HT2 receptor stimulation. The nonspecific 5-HT receptor agonist (and 5-HT2 receptor antagonist) quipazine also induced "wet dog shaking" at doses which suppressed aggression, social interest, and exploration but increased inactive behaviors (sitting and lying). The discussion delineates a specific role for 5-HT1B receptor-subtype involvement in the modulation of aggression, with the restrictions we clearly face with regard to the lack of specific serotonergic agonists and antagonists for certain receptor subtypes. By and large, male and female rats react similarly to treatment with serotonergic drugs, and this fact underlines the consistent role of 5-HT in different forms of aggression. Edited by: Alfa
     
  3. snapper

    snapper Gold Member

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    From several generations past, my lab rats found this substance very
    toxic. Non-specific MDA like high without a whole lot of euphoria and
    threshold visuals. Some nausea at come up, and electric sensations which
    slowly increased in intensity, ultimately to evolve into stabbing pains in
    SWIM's labrat's heads. Poor rats though they were gonna die, but survived
    with a hangover and probably some brain damage. Dose as swim recalls
    was 100mg with 100 mg BZP. BZP was never a problem on its own (if fact,
    the rats liked it..), but this stuff is nasty !
    Note many at the time really liked it, but my rats were not the only
    ones to complain. No loss for the Japanese IMHO.

    Snapper
     
  4. astenu

    astenu Silver Member

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    i was wondering about the bzp/TFMPP combo too. there seems to be some really good reports of mdma like buzz going on but a # of reports are negative & mention an overall toxic feeling. i'm wondering if maybe the dosing is too high and if smaller doses would be free of side efx
     
  5. Alfa

    Alfa Productive Insomniac Staff Member Administrator

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    That's a different topic.

    TFMPP
    When combined with BZP has mild hallucinogenic effect simular to ecstasy (MDMA), but does not have the emotional (empathic) effects of ecstasy.
    TFMPP affects the dopamine and noradraline system, like BZP, but more significantly the serotonin system.

    Effects:
    • increased sociability
    • mood elevation
    • hallucinogenic effects that have been reported to induce tactile sensations, visual and audio hallucinations (more signaificantly when combined with BZP)
    • stimulant effects that may include increased heart rate, blood pressure and body temperature (note generally not significant unless in doses around 100 mg+)
    • increased alertness (not nearly as significant as BZP)
    • dilated pupils
    • dehydration
    • Sore thoat or nasal passages when snorted
    • stomache pains and naussea (usually associated with BZP combination)
    • significant hangover effects that may last for several days
    Contraindications:
    • not for people with heart of liver disease
    • not for people with mental health problems
    • do not combine with MAOI
    Reccomendations:
    • first time users should start with half the recommended dose
    • drink enough to avoid dehydration
    • does not mix well with alcohol
    • do not use products without full ingredient list
     
  6. Cuberun

    Cuberun Gold Member

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    SWIM think tfmpp is quite awful and not really worth it, rapture is a common brand. not too fond of bzp/tfmpp combos either but bzp on its own can be decent if nothing else is available.