My cat is a small-framed, calico female. Her sister is small, her brothers are big, so this is her body type: small. Excuse my time frames because my mind is a little messed up right now-sober, but messed up. A couple weeks ago now I noticed she was "hiding" but at first I attributed it to the heat because when I gave the cats a treat of wet food or something, she'd still come out to eat so at this time, as far as her appetite was concerned, she was fine. Then I noticed she wasn't eating anymore. I'd open something, she'd come, sniff, leave and eventually not come anymore. After 3 days (yes, I know a cat that goes without food or water for 2 days will become sick but I wasn't aware she wasn't eating ANYTHING, I just knew she wasn't eating the wet food) I made a vet's appointment for her. We brought her in. Found out: after the last time she was in heat (her brothers are neutered mind you) her cervix or something didn't close up properly therefore leaving her uterus open and it became infected. She needed to be spayed the next day and put on fluids for the night. So she was. So, time passes- after surgery and coming home. She was eating a bit of tuna and a few peices of dry food here and there. I gave her tuna because that's what she wanted to eat so, if that's what she wanted- eat! I gave her whatever she would eat because it was better than nothing. She was drinking on her own. Even a couple days after surgery she was already walking around, washing herself, purring, kneading, etc....she still wasn't eating as much as she used to but she was eating. She meowed a lot but this could have been due to pain (she was given pain meds-tramadol and some antibiotics- bioclav) or being kept in the bedroom sometimes so I could monitor her food intake. Anyhow, the vet wanted to see her back there about 3-4 days after surgery. They weighted her. She weighed in at 4 lbs. Small yes, but she is already, although I agreed she needed to gain more because the shape of the body from an aerial standpoint wasn't back to normal. So they said, we're going to put her on an appetite stimulant. I said okay. I didn't even think to ask what it was or anything, I just said "okay" because.... The next morning: vicious. And this is coming from a cat who was overly affectionate, sometimes annoyingly so. Also, she was the stereotypical great jumper/climber/etc...more so than any of my other animals. I left and called the vet's office. The first question I asked them was "what medication did you administer to Emily yesterday?" Mirtazapine. The viciousness went away and she was left completely disoriented (for lack of a better word but completely understates her contrast in mind/body). I tried to stay positive telling myself if I knew what the appetite stimulant was, I would have said no, and then she wouldn't gain weight (I assumed) so maybe , even though this looks terrible now, maybe after the drug subsides it will be better. She could not eat dry food although she tried with fury because she was hungry but was too stoned to grab it. She could not drink anymore. She could not see well or turn around. She could not back up or hold herself up well while walking. She did walk and walk though and barely slept, if slept at all. She would walk into things and through things. She would walk into a wall and stare, etc... Terrible shit to watch. 6 days later: She is eating wet food but has a hard time holding herself up to eat it sometimes so I'll reposition her arms and legs for her. She was eating wet food before they gave her the medication. She cannot eat dry food well although she tries but often just walks through the dish or falls into it. She does not drink on her own, I have to add water to her food and also force feed her water. She sleeps more now but is tight, muscle twitching beyond normal cat-dreaming muscle movements. She is tight while she does it and it reminds me of when I'm on too many meds and when one relaxes into bed, the muscle twitching begins. She still takes time to see properly it seems. She still has trouble turning around or backing up. She goes beside the litter box as opposed to in it. She is better than she was 6 days ago but it seems is on and off with symptoms. One day she can seem more spry and the next as if she's gone backwards again. She sometimes still stops at walls but that has gotten better. She still loses her footing quite often. She does not wash herself or purr. She still seems quite disoriented. I called the vet's today and she said it's unlikely the mirtazapine and could be something else wrong. I told her no, it is the mirtazapine because she was not like this in ANY way before or after surgery and this only began after she was given the drug. I asked her how much she was given. She said, a quarter of a tablet. I said, how many mg's is that and she said well, I'd have to go and check the bottle. I said, okay. She came back with 3 mg's. So...whether that's true or not, who knows because obviously they don't even want to admit the mirtazapine is having a terrible fucking effect on my precious animal. But 3 mg's could very well likely be the truth. A human being is often started on doses ranging from 7.5 mg's -15mg. So- 3 mg's to a 4lb cat. Anyone want to do the math for me? How many mg's appr. would that work out to for an average weight human. Yeah, I thought I'd whip out paper and it would be easy so perhaps I've killed some brain cells because I was left staring. So first off- I never would have agreed to her being given this crap had I of known. After surgery she was doing pretty damn well for it being JUST AFTER SURGERY compared to -this-. So, why hasn't the drug left her system yet or did they screw something up for good. Please- any comments, advice, thoughts, facts would be welcomed. I'm stressed out and watching my baby like this is not something anyone should have to watch. She doesn't deserve this. So- 3mg of mirtazapine to 4 pounds? Seems like a lot now that I know the starting dose on an adult human. So let's say the adult human was 115lbs. 3mg to 4 lbs for a feline is the equivalent to the human's dose being ___________. I feel so stupid, my brain goes blank. Plus one has to take into account the different enzymes in each species. And anything else anyone would like to say, ask or add. To be repetitive- She is better than 6 or 5 days ago BUT should AT LEAST be able to walk normally by now I would think. She is on and off getting better. If she never had the damn drug given to her, she would have been more or less back to normal her by now. She was already on her way- I hope more than anything still is but I'm open to hearing the good and bad anyone might have to say. Need to know. Thanks. Long, "hard to follow" post!