I am looking for experienced users of Tianeptine to answer a few questions that don't seem to have been covered anywhere else that I could find. I did a lot of searching so hopefully there is someone out there who might have been in a similar situation. I also posted this at another popular harm reduction forum to try and get a thorough answer from everyone out there. Recently, Tianeptine has been shown to not be an SSRE, as previously thought. From what I understand it exerts its effects mainly through AMPA and NMDA, and affects opioid receptors. This brings up some interesting questions about cross-tolerance. In my case, I'm a daily Kratom user, and have been for quite a long time. Kratom has been said to have some effects on Serotonin (although this may not be that important in regards to Tianeptine if it actually is *not* and SSRE), and we all know Kratom also affects opioid receptors. What, if any, do you guys think the dangers might be of combining Tianeptine and Kratom? Does anyone have any experience combining Tianeptine with any other opioid agonists (hydrocodone, heroin, morphine, etc.)? If so, did you find signifcant cross-tolerance or any reduction in effects from the Tianeptine? I'm most interested in anyone who has any info on using it while also being dependent on Kratom. Actually, to be more specific, I'm not really looking to *combine* Kratom and Tianeptine. I plan to take them at separate times, possibly using the Tianeptine to greatly reduce the frequency of my Kratom use. I'm just worried that having a base opioid tolerance is going to render Tianeptine pretty much useless. Who here has used Tianeptine while dependent on Kratom or other opiates/opioids? Any information is greatly appreciated!