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Oral use - To Potentiate Oxycodone

Discussion in 'Oxycodone' started by Scarymary51, Jul 24, 2013.

  1. Scarymary51

    Scarymary51 Newbie

    Reputation Points:
    Jul 22, 2013
    Female from U.S.A.
    My friend has read that Meclizine can help potentiate the effects of Oxycodone. Is Meclizine taken at the same time as the dose of Oxycodone of a period of time before? Thanks.
  2. BigDiggerNick

    BigDiggerNick Banned

    Reputation Points:
    Jul 3, 2013
    Male from U.S.A.
    Meclizine will potentiate it but not as well as others. Tagamet and Cyclizine are much better potentiators.

    To potentiate it, take the meclizine 30 - 45 minutes before your dose to give it time to matabolize and start working. You might also want to take an antacid like tums soon before you dose. Oxycodone and many other substances absorb better in more basic solutions.

    Lots of other substances can be used as well. Meclizine will just add to the sedation so be careful of falling asleep.

    Some other substances that may be better:

    DXM - helps keep tolerance low and potentiate it
    Diphenhydramine - like meclizine, will add to the sedation
    Tagemet - Processed through the same enzyme, which will prolong the high of the opiate
    Cyclizine - Adds more euphoria
    Tonic water - quinine is a good potentiator as well, not as good as quinidine, but unless you can convince your doctor you have malaria, your probably not going to get it.
    Grapefruit Juice - make sure its white and not from concentrate. Like tagemet, it prolongs the high.

    Be sure to take these substances before you dose.
  3. baZING

    baZING Newbie

    Reputation Points:
    Nov 15, 2009
    Male from U.S.A.
    There are many, many threads on this topic so in the future, please try using the search engine before posting. I understand that you were asking about meclizine specifically, but there is enough information in other threads to basically answer your question. In terms of opiate potentiation, first-generation antihistamines are the only antihistamines that really do much, and even then IME they barely add anything to the actual high, just cut down on itching. For your reading pleasure, here are a number of threads on opiate potentiation:

    Possible Grapefruit Juice Potentiator for Greater Tramadol Experience

    Opiate/Opioid Potentiating Guide

    Potentiating Morphine

    Grapefruit Juice/CYP2D6: clarifying a common misconception

    Codeine, dihydrocodeine, and grapefruit juice

    Anyway, that should be a good start.