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Combinations - Tramadol and Marijuana

Discussion in 'Drug combinations' started by Mr. Bob, Apr 9, 2009.

  1. Mr. Bob

    Mr. Bob Newbie

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    SWIM did a quick search and there didn't seem to be a thread about Tramadol and Marijuana yet... So here it is! :)

    SWIM has experienced intense pleasure with Tramadol and Marijuana. He first took the Tram. and as they were kicking in began to smoke. They have amazing synergy, so the high lasts for a very long time.

    SWIM has also used antacids for propentiating the Tramadol while combining Marijuana and had no problems at all. Just hours of pleasure. :thumbsup:

    Be sure never to combine anything with Tramadol you are not supposed to. I have not posted 50 times yet so I cannot leave an interaction link. Be sure to google any drugs you intend on taking with Tramadol. It has many dangerous interactions.
     
  2. RoboCodeine7610

    RoboCodeine7610 Silver Member

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    True, Robo got a chance to try this out today and it is absolutely amazing.The bad serotoninergic/jittery effects can't be felt and the opioid effects are at least 3 times as strong as usual.

    Plus, studies show that marijuana can prevent or lessen the severity of seizures.Just in case...

    Robo
     
  3. Troussman

    Troussman Titanium Member

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    SWIM agrees its a nice combination, pretty euphoric and a long lasting mellow opiate high. Definitely seems like weed potentiates the tramadol.
     
  4. Tigey

    Tigey Newbie

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    Tigey is a bit worried by this advice. While yes, cannabis has been shown to reduce seizure risk in some populations, Tramadol carries increased risk of seizure, with incidence of seizure found to be independent of dose in an Iranian study (Talaie et al., 2009 - published in Journal of Medical Toxicology, 5(2), 63-67).

    Further to that, Tramadol has been shown to increase the risk of seratonin syndrome with SSRI's and pretty much anything else that decreases seratonin levels. McGill University and University of California studies published in 2007 showed that while cannabis in small quantities increased seratonin levels, in large quantitites it dropped seratonin levels (and fyi, also increases pain levels - for those who're thinking of taking the two together under MMJ+Tramadol prescriptions).

    To quote from 'Alcohol and Marijuana: Effects on Epilepsy and Use by Patients with Epilepsy' (Gordon & Devinsky, 2001 Epilepsia, 42(10), 1266-1272):

    Epilepsy Ontario said (website, 2011):

    An Australian study said:

    and

    Basically, cannabis can in some individuals, on it's own, increase the seizure threshold in seizure prone individuals (including myself). In others, it can lower the seizure threshold. This appears to depend upon type of seizure and potency + amount of cannabis, from studies to date. Most studies showing a protective effect were done with induced seizures and with very small amounts of THC - it may be that some compounds present in smoked joints do other things.

    So basically, combining the medication which is most likely to cause you a seizure if you haven't had one before with something that can make seizures more likely is potentially an unsafe way of taking both drugs. For that matter, I'd suggest taking tramadol around other people if this is your drug of choice - fitting out or even having an absence seizure for the first time is a scary and severely unpleasant experience I wouldn't wish on anyone*, but it's much better if someone else is around to help, and that they know potential side effects and OD effects of the drug you're taking.

    The fact that weed potentiates tramadol in some individuals should be a clear indication that it can potentiate not only the high but also complications of tramadol use in some individuals.

    all the best,

    Your friendly 'safety first, steak second' tiger.

    * if someone does fit out, drop and start twitching (what used to be called 'grand mal' and is now called 'tonic-clonic'), grab them a pillow/something soft to put under their head - don't restrain them. Get anything sharp or hard out of their way ideally without moving them, and if it's lasting more than 5 minutes, is their first seizure, or they go from seizure to seizure without coming round first, call an ambulance. Paramedics will almost never (I'd say never but there's always one) care about recreational drug use, they're just there to help and that's all they'll be focusing on. While it's very rare that someone will have an obstructed airway (and the tounge swallowing thing is pretty much a myth), if they've just eaten or are on a whitey/OD when they fit, puking is more likely and more dangerous, but will usually happen when consciousness comes. Don't give food or drink til the person is fully conscious. As they ease up, move them onto their left hand side in what you can remember of the recovery position ;), and try to be an easy-focusing distance away to reassure them as they come round. Also, if you're freaked out, it's better to call for help than look stuff up on the internet when you can't remember this advice. You can always cancel help once you've called for it.
     
    Last edited: Nov 13, 2011
  5. RoboCodeine7610

    RoboCodeine7610 Silver Member

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    Very good information, nice research.

    Robo really wasn't sure about that fact but he wasn't implying that one should take a higher dose while on weed, but merely as a curiosity.

    Robo
     
  6. Tigey

    Tigey Newbie

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    Thanks and no worries :) always nice to find someone who's okay with critique of post and doesn't take as critique of person.

    Thanks also for clarifying. I was happy that you posted about seizures as it gave me the nudge to post about both issues - tramadol being awesomely seizureful and also weed use having odd results in seizure studies.

    From Australian Prescriber via St. Vincent's hospital - I've trimmed bits to avoid over-quoting (want it to be fair-use, but think it's a public bulletin anyhow). Emphasis is mine:

    While the forum guidelines discourage linking out in favour of info in posts, the rest of this article is at: Australian Prescriber and is well worth a read.

    Specifically, drugs.com's drug interactions database says this about the reaction between Marinol (synthetic cannabis) and Tramadol:

    .

    It's also worth noting that in rat brains, Cannabigerol (CBT), which is the biosynthetic precursor of CBC, CBD and THC, inhibits the uptake of serotonin, as does THC (more strongly, in fact). (Source: Russo, E., Cannabis therapeutics in HIV/AIDS, 108.). This means that the info on Tramadol and SSRI's below may also be worth being aware of:

    Tramadol is one of the most 'interactive' drugs - it has more than 600 known drug interactions, and as such, perceived benefits in creating a recreational drug cocktail may be outweighed by the risk of unexpected side-effects, especially in cases of 'laced weed', for instance Tigey's friend Mr. Horse's old favourite, PCP-dusted weed.
     
  7. el k

    el k Newbie

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    tramadol and speed meth..seems to be a bad mix...with serotonin syndrom like....
    And buprenorphine and LSD was looking to make a similir problem...between brain receptors...
    try it with care if gonna do such kind of mixes...bad feeelings times..
     
  8. swirlierswirl

    swirlierswirl Newbie

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    twizz mixes this concoction a fair bit: a few tram., then a joint... another... etc. It's funny 'cause the girl in question often finds a fair bit 'o' tram will make her extremely hyper, though with weed, she'll sometimes need a little snooze (depends on the draw and a million other factors, though). Although, she's also on SSRIs (citalopram, 20mg) but not a particularly high dose and has been fortunate enough to never experience a seizure (despite taking quite stupid amounts in past...), BUT - has experienced hallucinations as a result of this combination, which was strange, surreal, unexpected and quite dazzling. And another thing she'll say for it, which is probably restricted somewhat to her (as everything effects everyone differently in different scenarios and all that/too thick to consider more than a couple of variables), such a combination seems to decrease tram. sickness (which she'd get after the euphoria/good mood had faded and the next day risen)