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Drug info - UR-144 Drug Info

Discussion in 'Cannabinoids' started by CannaFun, Jan 25, 2012.

  1. CannaFun

    CannaFun Silver Member

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    Please post info about UR-144 here.

    Can anyone add information about:
    • names / synonyms
    • molecule
    • dose
    • duration
    • side effects
    • have there been any reported incidents with this compound?
    • since when has this research chemical been available?
    • legal status
    • stability of the molecule / compound
    • links to news articles about the drug (in our news section)
    Experiences with UR-144 are discussed in the following thread: UR-144 Experiences

    _____________________________________

    Short Name: UR-144
    Synonyms: 'KM X-1'
    Full Chemical Name: (1-pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone
    Molecular Mass: 311.5 g/mol

    [​IMG]

    Legal status in UK: Uncontrolled.

    Legal status in US: Not explicitly controlled at Federal level, though may be deemed a controlled substance analogue under the Federal Analog Act under certain circumstances. Legality under state law will also vary depending on the specific legislation in each state.

    _________________
    (end mod edit)


    SWIMs pet found a bag on the street, labeled 1g UR-144. It contains 1,078g of bright white powder. Compared to this one, pets JWH-122 looks dirty-white. Texture is not as clumpy as most JWHs.

    Smell test: odorless
    Oral probe: tasteless. grainy, like fine sand

    SWIMs pet uses 5% blend strength here, he doesn't know the chemical yet. As comparison, he uses 10% strength for JWH-210. 5% strength for AM-2201 and JWH-122. Most of the (expensive) commercial blends are almost on par with pets blend strength, some occasional ones are even stronger.

    [T+0:00]
    2,5mg (0,05g of blend) smoked via bong
    light stoney effects noted like a tiny dose of JWH-122

    [T+0:02]
    15mg (0,3g of blend) smoked via bong
    1 minute after exhaling, SWIMs pet feels already a good stone, equal to a 10-15mg dose of JWH-122, together with a warm body glow and relaxed muscles. Pet also noted a light head high, which is really VERY high. I mean trippy. Feels more like a low dose of MXE added to a good bowl of JWH-122 blend.

    [T+0:40]
    body stone fades, trippy MXE-like high remains.
    Redosing. Again 15mg via bong.
    Immediately after exhaling, the body stone returned, which pet would like to describe as almost benzo-like. As expected, the high got even more trippy and dissociative.

    [T+1:30]
    stone fades again, head high remains

    [T+2:15]
    head high fades (some slight confusion remains though)


    At first sight, this stuff seems on par with AM-2201 for SWIMs pet. Not really stronger, but extremized effects in both directions, stone and high. Might not be everyones taste, this high doesn't have very much of a MJ high. Feels more like Benzo+MXE. But still enjoyable. Very enjoyable in fact. Definitely needs more research :)

    Be careful, beginners should start @ 0,5-1mg with this chemical (as they should with AM-2201), and make blends a lot weaker !!
    Withdrawals might be worse than AM-2201! Stay safe!
     

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    Last edited by a moderator: Aug 27, 2016
  2. syntheticdave

    syntheticdave

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    Sounds like an interesting compound, possibly a good replacement for AM-2201 as its soon to become banned in the USA.
     
    Last edited: Aug 5, 2013
  3. CkenX

    CkenX Silver Member

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    How is it that a cannabinoid with such little selectivity for CB1 receptor be so psycho active? Maybe there is far more psychoactivity to CB2 than thought, or the sample was really something else. I'm interested to learn more.
     
  4. Shampoo

    Shampoo entity of sorts Staff Member

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    The old dogma that CB2 receptors only mediate peripheral effects is, at least in the scientific community, abolished. CB2 receptors are present throughout the central nervous system, and have been shown to mediate some drug-related behaviors, including those of cocaine. They are present in such crucial regions as the nucleus accumbens and ventral tegmental area, as well as the prefrontal cortex and a number of other limbic regions.

    Furthermore, affinity is merely a measure of the kinetic midpoint of interaction between a molecule and a protein. It says nothing of activity, only the strength of the physical relationship (and even that has many other factors which may come in to play, such as dissociation kinetics). The affinity of a molecule for a receptor is a good first clue to it's activity, but there are far better measures, such as those which measure actual efficacy like GP-release assays and downstream measures such as GDP-GTP conversion assays and in this case, Ca2+ release assays. While affinity is a general correlate of activity, there are plenty of compounds with high affinities and low activity, and vice-versa.
     
  5. CannaFun

    CannaFun Silver Member

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    Maybe it's an NMDA receptor antagonist, like HU-211 is, with additional CB2 activity. This hasn't been tested, or has it? This would mean effects like Keta, DXM, MXE, etc., which are NMDA receptor antagonists too AFAIK.

    Just an uneducated guess though. SWIM doesn't know much about this science, but would be very interested to hear more technical background.
     
  6. Synesthesiac

    Synesthesiac R.I.P.

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    The dosages in the first post are very high, I'd highly avoid starting with 5mg or so, I've found it active at sub milligram dosages.

    I put 1mg of ur-144 in a rollie and smoked. Effects did not peak until a good 3-5 minutes after smoking, which is rare compared to most synthetic cannabinoid type drugs that tend to peak in effects nearly instantly. The effect was very cannabis like, I'd go as far as saying this has a much more cannabis like buzz compared to any other synthetic cannabiniod I've tried; even more so than the jwh series. Felt very monged out, however focus and interest in tasks was greatly improved. Did not feel very socialble on it; but I never feel very socialble on cannabis or other cannabinoids anyway. 0.5mg gave very subtle effects. Very promising chemical overall, I'd say the nicest non-canabinoid cannabinoid receptor agonist that's become widely available since the cannabinoid bans.

    * Very low evaporation temparature
    * Delayed onset
    * Tollerance after just one day of 1-2mg redoses is quickly becoming apparent
    * Very smooth taste
    * High doses give very different effects to small "normal" dosages. 4mg (with a days tollerance) was uncomfortably strong for me, much more psychedelic than most cbds.
     
    Last edited: Jun 4, 2012
  7. bloodshed344

    bloodshed344 Newbie

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    I can personally vouch for everything you said on the dot, except I have smoked about 15-20 mg at once and had a nice trip which I enjoyed. Definitely psychedelic. I love the fact that my cannabis tolerance has actually gone DOWN since I started smoking UR-144. That's right, I'm getting way higher off of both cannabis and UR-144 than I have gotten from just cannabis alone in years. This thing has an awesome tolerance, fuck full agonists!

    The delayed onset aspect is nice because I don't like the high to be instant, creeper weed is the best.
    The taste is completely undetectable and when I vaped it by itself the taste was not bad at all... the most neutral tasting thing I've ever tasted besides water.
    I take my bud, mix a bunch of UR-144 with some finely grinded weed, make sure to really press it in and mix well, load my bowl with it then put a few sprinkles of UR-144 on top. If I want to just get UR-144 I hold the lighter above the bowl and move it down slowly until it all evaporates. Doing this I can make a bowl like that last 4 or 5 hours.

    The high feels slightly incomplete without cannabis in my opinion though, even the smallest amount evens out the high and gives a much more relaxed body feeling. I do like the fact this high is very focused, sativa-like, and even stimulating if you do a bunch at once, but then when the intense high wears off if you're already sleepy then you feel extremely tired and relaxed... of course you can get back up there again but don't do it too often or you'll get a bad tolerance.

    I'm pretty sure tolerance with this is even shorter than tolerance with weed.

    Overall UR-144 is a winner in every aspect. Especially price, 20$ for 250-500 doses (if prices aren't allowed I can take this down)
     
  8. charliemiami

    charliemiami Newbie

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    What is UR 144 soluble in ?
     
  9. Docta

    Docta Idiot Savant

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    Orientation corrected isomer image.

    [​IMG]
     

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  10. yacutanfire

    yacutanfire Newbie

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    My pet Monkey whispered to me the other day and said that UR-144 is not a stoned type of religious experience but definitely a euphoric Indica realisation, nothing like a benzo or MXE there is no dissasocciate experience with UR-144
     
  11. AMKR

    AMKR Newbie

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    I haven't seen anyone note this yet, so I thought it would be useful or at the least interesting information to post. Doing a little cleaning on the lab I found an old batch of UR-144, that has since changed color, it is now a strange greenish color? Think it could be oxidization? Upon testing - No other changes noted. Struck me as odd.

    AMKR added 8 Minutes and 10 Seconds later...

    I can concur with all synthetic noids needing a lil bit of cannabis to feel truly complete. None of the Synthetic noids really take off the "edgy" feeling and relax your body like good ol' delta 9 THC and endo-CBDs. UR-144 is however much more pleasant in the fact that it mostly hits CB2, which I hypothesize to mediate most of the therapeutic side of MJ, but then again my logical side says that it could also have something to do with the fact that THC/CBDs are unselective (kind of floating around, but never attaching to the receptors) and JWH/AM/UR/RSC/etcetc - actually binding to the CB1 and CB2 sites.
     
    Last edited: May 30, 2012
  12. Shampoo

    Shampoo entity of sorts Staff Member

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    Care to explain this? ∆-9-THC and CBD absolutely bind to CBRs. Where does this information come from?
     
  13. syntheticdave

    syntheticdave

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    Would UR-144 be soluble in the typical cannabinoid solvents such as Acetone, Propylene glycol, and High Proof Alcohol?
     
    Last edited: Aug 5, 2013
  14. barndtman84

    barndtman84

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    Ur-144 will dissolve in 100% acetone which is how i dissolve it and 5F-UR-144 for my herbal incense blends i make or use as close to 100% grain alcohol but i prefer acetone but not nailpolish remover espcolored solutions as everything besides acetone will stay on whatever you smoke/vap...i love ur-144 and its new big brother 5f-ur as they are very close in effects to its illegal counterparts but also many of JWH series causes jitteryness paranoia and i have a unfortanetly high tolerence. But if anyone needs to know anything specific about any of the Abbott Lab series of noids i can hopefully answer and i dont sell it if anyone was thinking that lol i just enjoy researching it lol.
     
  15. barndtman84

    barndtman84

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    has anyone ever vaporized it cuz i am trying to find the best ROA or way to smoke or vap it and it has a pretty high burning temp this is the ur-144 the 5f-ur-144 is much lower so i have found but i dont know if there is a more efficiant way to smoke/vap it as i just dip a cigg into a bag of some ur-144 or 5f-ur-144 and smoke that but i know the filter is working against me lol. any tips would be sweet thanks.
     
  16. peezee

    peezee Silver Member

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    Vaporizing is technically the best ROA.

    But making a good smoking blend, containing something like mullein, damiana and/or marshmallow leaf would probably be better on your tolerance, even in the short term. Which means less withdrawal, something you'd really want. It's easilier managable once in a blend, and probably also better on your lungs, assuming you're not using tobacco.

    My 0.02$
     
  17. davidude

    davidude Silver Member

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    Can anyone comment on the legal status of UR-144 and 5FUR-144 after the upcoming federal ban in the USA?
     
  18. Phenoxide

    Phenoxide Super Moderator Staff Member

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    Not explicitly controlled but almost certainly covered by the Federal Analog Act. In my opinion it'd be extremely foolish for any distributor to sell such substances within the US if the bill is signed into law with the current wording. It'd be an open invitation for federal prosecution.
     
  19. Alicia

    Alicia Gold Member

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    I postively adore this substance and appears more forgiving then AM2201 specially when it runs out. The high is more there as well comparing to AM2201 which is brief and morish.
     
  20. SPECTRE

    SPECTRE Newbie

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    Yes, acetone does seem to work best for most analogs.

    To counter the paranoia and anxiety, try using St John's Wort the main base (for numerous ailments including anxiety and migranes), with some Mullein (better for the lungs) mixed in about 20% and Elephant's Head (for it's calming effects) at 20% Pleasant taste, too.