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Addiction - Wellbutrin at the beginning of opiate withdrawal?

Discussion in 'Antidepressants' started by apiffini, Nov 20, 2011.

  1. apiffini


    Reputation Points:
    May 5, 2008
    I have a bunch of sample bottles of wellbutrin, 150mg and 300mg. I'm supposed to take them but have neglected to do so since I've been addicted to approximately 60mg of oxy per day.

    I'm down to my last 20mg and was wondering if anyone has experience with starting the wellbutrin during withdrawal, will it help?
  2. C.D.rose

    C.D.rose Donating

    Reputation Points:
    Jan 14, 2006
    Hmmm, [noparse]bupropion (Wellbutrin, Zyban)[/noparse] is used as a smoking cessation aid, so there is some sort of way one could imagine it to be useful in [noparse]opiate[/noparse] withdrawal, but... that's a very long stretch, and I would say it's probably too long. Technically it may help somewhat, but there is a chance that you may experience side effects that completely offset any potential benefit.

    And that's not even to talk about other (possibly serious) issues that could arise. [noparse]Bupropion is an inhibitor of a liver cytochrome that plays a role in the metabolization of certain drugs. (A quick Google search yields CYP2D6, but I actually think it's a different one. I'll have to look at that some more.) That means that it slows down the metabolization of other drugs that use the same enzyme, and I think that hydrocodone is one of those drugs. It may affect oxycodone as well. This all means that it would probably not be a good idea to start taking bupropion at this point in time.

    More generally, I wonder why you were supposed to take bupropion, but decided not to?[/noparse] If whatever you were diagnosed with is still present, it might be a good idea to check that out and look at whether you may need some help with that. But that is up to you of course...
    Last edited: Nov 20, 2011
  3. PunchThomas

    PunchThomas Newbie

    Reputation Points:
    Sep 28, 2011
    If you're physically addicted, meaning you become sick if you stop taking opiates, welbutrin won't make you better.

    But both opiates and wellbutrin work by stimulating the dopamine pathways in your brain, so I believe it can help with the psychological side of addiction. Wellbutrin is in a class of antidepressants by itself, since it does not work as an SRI like most others.

    If you can get yourself off of opiates to the point where there is no more psychical sickness, wellbutrin can help control the desire to go out and take more.

    PunchThomas added 1 Minutes and 55 Seconds later...

    That's PHYSICAL sickness. Apologies. Wish there was a way to edit a post once it's posted
    Last edited: Apr 13, 2012
  4. cogumelo

    cogumelo Silver Member

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    May 12, 2012
    As they have said the wellbutrin is an antidepressant, will help the desire to use drugs, but the physical withdrawal symptoms will not end. The best thing to do is lower the dose gradually using a opioid safer. Or try some of the experimental treatments with drugs such as ibogaine (search fot it at wikepedia) that has shown good treatment, just do not know if it will be easy to find. Remember also that the effect of bupropion will take at least 14 days to start, usually peaks after a few months.
  5. BigWillyStyle

    BigWillyStyle Silver Member

    Reputation Points:
    Oct 14, 2008
    If someone started taking opiates in the first place because of depression, then wellbutrin might help them out because it acts sort of similarly to opiates but much more gently and slowly. Opiates release a flood of dopamine, wellbutrin is going to very slowly raise the water level of the lake of dopamine (and norbupe, so it will give more energy as well) in the brain. Because of its long time to maximum efficacy, wellbutrin will probably note alleviate any immediate WD symptoms BUT it may help to fix whatever imbalance caused someone to seek out opiates in the first place. And help keep PAWS away too, which for most is the hardest part.
  6. AddyCrazy

    AddyCrazy Silver Member

    Reputation Points:
    Nov 6, 2007
    I wouldn't recommend starting Wellbutrin during withdrawal. I am on it and in the beginning it is very stimulating and may cause anxiety and restlessness. Since you will already have plenty of that during your WDs I wouldn't advise it. But after WDs an antidepressant is very useful for people who do drugs to mask emotions like anxiety or depression.
  7. Minglewood

    Minglewood Newbie

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    Jun 20, 2011
    Correct! Yours is the only helpful answer on this thread. Wellbutrin is a noradrenaline reuptake inhibitor. The main cause of the anxiety, restlessness, high blood pressure, nervousness, and insomnia of opioid withdrawal is the fact that during withdrawal noradrenaline production increases. Since noradrenaline reuptake inhibitors keep the noradrenaline in the blood much longer, the opioid withdrawal will be much faster and harder with a noradrenaline reuptake inhibitor. First go through the physical withdrawals (3-4 days for most people, but up to 7-10 days for some), and then Wellbutrin can be very helpful during the Post Acute Withdrawal phase. Though some say you should just stop cold turkey from opioids, the temptation to relapse is also much greater than if you taper gradually. I have withdrawn a few times before after surgeries, and my last was a full shoulder replacement, four months ago. I went from 120 mg per day of oxycodone to 60mg per day with mild withdrawal symptoms (flu-like, sneezing 25-30 times in a row, runny eyes, coughing up handfulls of phlegm, a feeling of glass in my joints (which became sand by the third day and just normal aches by the fourth), insomnia & restless leg syndrome). Going from 60 mg per day down to 45 mg per day (After hovering at 60 mg for about a week) was nowhere near so bad, but the sleeplessness and restless legs continued. I found that 5 - 10 mg diazepam allowed me to sleep. Now I have been at 45 mg for a week and plan to reduce to 30 mg per day. During pain from physiotherapy, I take up to 50 mg codeine, which though equivalent to 5 mg oxycodone, I find much less addicting. Perhaps it is because codeine is relatively "organic" compared to the semi-synthetic oxycodone. When I get down to 30 mg per day for a week or two, I will switch to 250 mg codeine per day (the equivalent of 25 mg oxycodone - it's a ten-to-one ratio), and then go down 20-50 mg codeine at a time, staying at each new dosage for about one week. It takes the average person 4 days for their body to achieve stasis, where it is producing enough of it's own endorphins again, but be good to yourself and give it 7 days to be sure. Try going from splitting your daily dosage from 3 times per day down to two. at 200 mg codeine per day, I take it 2 times 100 mg separated by 12 hours. By the time one is down to 100 mg codeine per day, it is best perhaps to take it all at once an hour before bed, so that your sleep is not interrupted, and you are going 24 hours between doses. After that you can go down to 80 mg for a week, 60 for another week, etc. For me, I get no withdrawal symptoms going cold turkey off of 100 mg codeine (10 mg oxycodone) per day, but others might want to just continue tapering 20 mg per day each week until down to zero.
  8. DiabolicScheme

    DiabolicScheme Titanium Member

    Reputation Points:
    Apr 5, 2010
    At be best it might help with some psychological pull of your addiction, but most likely it is going to increase the Side effects of oxy withdrawal, specifically anxiety/panic.

    It's also going to have a negative effect on sleep, when in opioid withdrawal sleeping can be a big bitch especially if you get restless legs syndrome.

    If anything can be recommended for withdrawal or to ease withdrawal symptoms I would recommend kratom. It should at the very least reduce withdrawal symptoms but be warned kratom has its own addiction risks but the main benefit is that its easy to get in most states, it has a ceiling effect (if you take too much you'll get nauseous and taking more doesn't increase the high at this point).
  9. ladywolf2012

    ladywolf2012 Titanium Member

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    Oct 28, 2012
    Before starting Wellbutrin, you must consider any other meds you are currently taking. For example, I take: Cymbalta, Abilify, and Modafinil. Wellbutrin increases the likelihood of seizures greatly with ALL of these drugs. Since opiate-withdrawal itself can cause seizures, I would be very careful and make sure that a good doctor has prescribed Wellbutrin for you for this difficult time in your life, and that you are not self-prescribing. Seizures are very scary and dangerous!