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what is the difference between Amphetamine(Speed) and Methamphetamine(Crystal Meth)

Discussion in 'Amphetamines addiction' started by xx79xx, Jan 29, 2013.

  1. xx79xx

    xx79xx Mercury Member

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    I have never done Meth but have done my fair share of speed pills and the "good' ones boy do they make you horny! Is it just me?
    Wow there is some REALLY good speed around here compared to what there used to be around 2007 or so...
    Whats the difference between "Speed" and "Meth"?
     
  2. Pyron

    Pyron Titanium Member

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    Re: what is the difference between Amphetamine(Speed) and Methamphetamine(Crystal Met

    Well, first off, I'd avoid using terms like "speed" because some people refer to meth and speed as separate entities, and some people use them interchangeably. Chemically, the actions that meth and other amphetamines have pharmacologically are pretty much the same, which is that they cause the release of massive amounts of dopamine into the synaptic cleft. This is not to be confused with cocaine or other psychostimulant drugs like Ritalin which are dopamine reuptake inhibitors. That being said, there isn't a lot of difference between meth and other amphetamines except for minor differences in effects and potency. Methamphetamine is incredibly powerful, and has a bigger effect than other prescription amphetamines but the core principles are the same. The differences come from what levels each of the neurotransmitters are balanced at that depend on what specific amphetamine substance it is, the most notable of which are serotonin, dopamine, and norepinephrine.

    However, there are most certainly amphetamine substances that are not at all like most other amphetamines or meth, the most commonly known of these being MDMA. While MDMA is a part of the amphetamine class, it's effects are considerably different, since they have much more to do with serotonin than with dopamine or norepinephrine. As a result the effects are different.
     
  3. JJ1234

    JJ1234 Silver Member

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    Re: what is the difference between Amphetamine(Speed) and Methamphetamine(Crystal Met

    Meth is both stronger and passes over the blood brain barrier quicker so it gives a better rush than regular amphetamine. Although regular amphetamine is a great high(if you are into that type of thing), methamphetamine is way better IMO. This also makes meth way more addictive too.

    Then you have to consider with even pharmaceutical grade meds that isomers play a role too. For instance an adderal is a mixed isomer amphetamine. I think most street produced amphetamine is too. Methamphetamine now is made mostly with ephedrine or pseudoephedrine giving only the D isomer which is a great deal more euphoric than the L isomer or racemic mixture. Enough about that though just know that meth is a great deal more euphoric, hits quicker, last longer, and IMO can steal your soul if you let it!

    I think comparing methamphetamine to amphetamine is similar to comparing heroin to morphine even though these drug classes are far apart. Like Heroin is to meth as morphine is to heroin. Both meth and heroin cross the BBB quicker than their counterparts morphine and amphetamine. They are also both stronger than each other and are the "king" of their classes so to speak. Sorry if this sounds misleading but it's how I view it.
     
  4. Dr.Evil

    Dr.Evil Titanium Member

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    Re: what is the difference between Amphetamine(Speed) and Methamphetamine(Crystal Met

    Here are the biological/chemical differences explained simply

    The difference is in their chemical structures there is an extra methyl group (-CH3) on methamphetamine. This has several effects that account for how different these very similar drugs are.

    1. Methampetamine is more lipid soluble. this mean it will cross the blood-brain barrier more quickly and enter cells faster than amphetamine will (this is the same difference between heroin and morphine)
    2. Methamphetamine is more stable than amphetamine. This means that it takes longer for the body to break it down (MAOs have a harder time acting upon it)
    3. I am not positive how the methyl group affects how strongly methamphetamine binds to its targets as compared to amphetamine but I would guess that it binds a little more broadly and stronger than amphetamine. This is because more lipid soluble compounds of the same class tend to have stronger binding
    4. Methamphetamine is metabolized into amphetamine. As you can guess this increases its strength a lot, because some of the Meth is converted into an active drug instead of being inactivated.

    Hope this answers your question

    ---Dr.Evil
     
  5. Phenoxide

    Phenoxide Super Moderator Staff Member

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    Re: what is the difference between Amphetamine(Speed) and Methamphetamine(Crystal Met

    The half-lives of the two drugs are actually very similar, both typically around 12 hours.

    Amphetamine is only a very minor metabolite of methamphetamine in humans, so its contribution to the effects of the drug is largely negligible. The N-methyl group that distinguishes between amphetamine and methamphetamine is rarely cleaved. Most of the drug is excreted unchanged, or with para-hydroxylation of the phenyl ring, sometimes followed by conjugation of the hydroxyl group.

    Metabolism of 14C-methamphetamine in man, the guinea pig and the rat
     
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