Health - Why does citric acid prevent DXM nausea? (dxm hydrocitrate vs dxm hydrobromide)

Discussion in 'DXM' started by El Calico Loco, Mar 15, 2007.

  1. El Calico Loco

    El Calico Loco Gold Member

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    The second time I did DXM, something told him to mix in 1/4 tsp of citric acid with the DXM solution (he was still melting Sucrets DM at that point). He discovered, to his delight, that doing so eliminated all nausea without seeming to affect the trip in any way.

    This was pure intuition - a hunch, or maybe advice from the Unseelie court. :) He didn't know why it worked.

    He thought it must have had something to do with the pH - DXM tastes extremely bitter, so he assumed it was extremely basic and that the citric acid was bringing the pH down to a more acceptable (to his stomach) level.

    Then he had the chance to test the pH of a DXM/ethanol solution (80mg/mL), and found the pH to be around 4 - fairly acidic, but less so than orange juice. This caused him to scratch his head. He thought that if it was the pH, then baking soda should work even better than citric acid.

    No dice. Taking DXM with baking soda made him throw up almost every time.

    He now thinks it must have something to do with the HBr. Bromides are known to irritate the GI tract. Is it possible that the hydrobromic acid (pH = -9!!) is cleaved off the DXM molecule before it is absorbed into the bloodstream, and that the citric acid then reacts with it in some way to neutralize it?

    That's just a guess, but he's not sure what else to think. All he knows is that one little quarter teaspoon of citric acid prevents all nausea, even when taking 1200mg of DXM, and doesn't seem to hurt the trip one bit.


    ECL
    (Bear in mind that he is using pharma-grade powder; he doesn't drink cough syrup.)
     
  2. geezaman

    geezaman Gold Member Donating Member

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    Re: Why does citric acid prevent DXM nausea?

    Snuffkin was lost at the deduction that baking soda should work better than citric acid? baking soda= alkali, citric acid =acid no?

    SWIM over citricized his DEX extraction, he ended up with about 100ml solution with 50g citric acid crystals dissolved into it, didn't test it, but it burned evilly, and the ensuing vomit tasted sweeter from start to end :)

    EDIT - 1/4 teaspoon of citric acid may cause benefit, the citric acid content of Snuffkins extract was ridiculously large. (ELC states they were playing with pharm-grade not extracts or syrup etc)
     
    Last edited: Oct 5, 2009
  3. Pinkavvy

    Pinkavvy Platinum Member & Advisor

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    Re: Why does citric acid prevent DXM nausea?

    hydrocitrate is easier on the stomache then hydrobromide
     
  4. El Calico Loco

    El Calico Loco Gold Member

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    Re: Why does citric acid prevent DXM nausea?



    I've heard as much, but how does that apply in this case? Remember, we're not talking about any sort of extraction as with Agent Lemon - the subject is simply mixing 1/4tsp citric acid in with his ethanol/DXM HBr solution before drinking it. There doesn't appear to be any sort of acid/base reaction before ingestion.

    Yet...it works every time. He's never gotten sick when he's added citric acid. He's often gotten sick without it. He's just curious as to what's going on under the hood. :confused:


    ECL