Why is the dose for alcohol so much higher than just about any other drug? This is a question I've been pondering for a while, and I wonder if the answer might give some insights into how and why alcohol affects the body in the way it does. A typical dose of alcohol for me is in the order of 70 grams: four 440 ml cans of beer at 5% ABV = 88 ml of alcohol or about 70 grams (Ethanol's specific gravity is about 0.8). I'm by no means a heavy drinker, and I assume that many people will consume in excess of 100 grams of alcohol in one session. This is several orders of magnitude greater than most other drugs, which are typically measured in milligrams or in some cases (e.g. LSD) micrograms. This suggests to me that alcohol must affect the body in a different way to most other drugs. At the effective dose levels, alcohol is not just a trace molecule that would be measured in ppm, it's a significant fraction of one percent of the body's water. Does anyone have any thoughts on this, or pointers to the mechanism behind alcohol's intoxicating effect?