Combinations - Zyban ( Bupropion ) and XTC...

Discussion in 'Ecstasy & MDMA' started by xpr´k, Aug 10, 2005.

  1. xpr´k

    xpr´k Newbie

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    im planning on quitting smoking soon'ish and one method i know is quite effective is zyban. I got told however zyban is actually an antidepressant which showed some interesting results on the smoking behaviour of the patient and thus got released as an antismoking pill. He also said it didnt really work all that well as an antidepressant but i cant confirm that.


    Here's what i found online about zyban :


    DRUG CLASS AND MECHANISM: Bupropion is an antidepressant medication that affects chemicals within the brain that nerves use to send messages to each other. These chemical messengers are called neurotransmitters. The neurotransmitters that are released by nerves are taken up again by the nerves that release them for reuse. (This is referred to as reuptake.) Many experts believe that [/i]depression is caused by an imbalance among the amounts of neurotransmitters that are released. Bupropion is unrelated to other antidepressants. It works by inhibiting the reuptake of dopamine, serotonin, and norepinephrine, an action which results in more dopamine, serotonin, and norepinephrine to transmit messages to other nerves. Bupropion is unique in that its major effect is on dopamine, an effect which is not shared by the selective serotonin reuptake inhibitors or SSRIs (e.g. paroxetine, Paxil; fluoxetine, Prozac;sertraline, Zoloft) or the tricyclic antidepressants or TCAs (e.g. amitriptyline, Elavil; imipramine, Tofranil; desipramine, Norpramin).


    My guess is anyone taking these pills should really stay of MDMA as it seems to work in the same area of the brain . Ive read somewhere dopamine is what damages the serotone receptors after XTC has made you brain use up a far larger then usual release of seretone .
    Zyban increases the amount of dopamine in your brain so logicly it would increase the damage . So if anyone here is taking zyban or planning to take it , remember to not drop while your doing it.

    if my assumptions are incorrect please feel free to correct me . I'm still trying to understand the workings of XTC .
     
    Last edited by a moderator: Oct 27, 2010
  2. Nagognog2

    Nagognog2 Iridium Member

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    That is a form of speed with no fun attached. It will make you feel like crap and wire you and cause you many sleepless nights. Forget it. Just quit the smokes and don't belive the hype of how terrible you will feel. I've seen many folk quit smoking and go through no withdrawl. So can you. Or don't. Take Zyban and become a basket case. It's speed and it's "supposed" to make you feel better. Uh huh...dogfood it will. It's a derivitave of diethylpropion: A diet pill. Yes it will mess your serotonin up. Yes it will mess your dopamine up. But remember you are giving up smoking! In exchange? You become a raving, sleepless nutcase! YaHoo!!
     
  3. xpr´k

    xpr´k Newbie

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    well i used it to quit smoking 9 months ago and i had none of the side effects you describe . In fact it worked beautifully , i had 0 craving for sigarettes and it kept me clean for 6 months.


    I made the mistake however to think i could smoke weekends only and after my holiday on which i smoked each day i just started again. Im now planning to quit again usingZyban (got someleft)after my B-day which will also be celibrated with the taking of some X :) .


    I recently re-discovered X after being 6 years clean and ive researched it alot since then . In doing so i also realized the combo of the 2 might be dangerous so i thought ide share the info.


    I decided for myself to leave at least 2 weeks between me taking X and starting up with the Zyban (prolly 3 to be safe). I'm also taking alot of care prior , during and after rolling to minimize the bad effect X has on my body .
     
  4. Nicaine

    Nicaine Titanium Member

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    Correct on the part about smoking. As far as how well it works as an antidepressant, that depends a lot on who's taking it. For those who suffer from lack of energy, lassitude, unmotivated type of depressions, it works very well. For the anxious or other types, it tends to work poorly. It's basically a stimulant that works on dopamine/norepinephrine, while most other antidepressants work on serotonin.

    Doctors tend to knock bupropion these days because they're brainwashed by drug company advertising, and bupropion is now a generic drug for the most part. Doctors want to push the latest/greatest and most expensive drugs, and they get free pens/watches/pads of paper with the names of new drugs written on them. "Old drugs" almost always get knocked. Of course, the older the drug, the more its safety profile is known, but who pays attention to that right? [​IMG] Edited by: Nicaine
     
  5. quinone

    quinone Newbie

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    I took wellbutrin (zyban) for depression and it was easily the best
    SSRI ive taken (and i've taken most of em lol). There were none
    of these effects that nago speaks of, but im sure those side effects do
    exist in some people. It was the most 'natural' synthetic
    mood-enhancer I had taken (over the period of 3 weeks I eventually just
    felt naturally happier and less depressed, as if it was in me the whole
    time, but I had just finally realized it).



    When it comes to quitting smoking, zyban is helpful, but having quit
    smoking myself, and seeing my father (a smoker of 40 years) quit, I can
    easily attest to the fact that zyban, nicoderm, etc. etc. are more or
    less a scapegoat so that ppl can 'feel' like they are quitting.
    If you want to quit smoking, you have to really WANT to, and that means
    just stopping straight up. Zyban and others just give ppl an
    excuse to feel good about themselves for 'trying' to quit, but often
    doesn't reflect that persons genuine desire to quit. If you want
    to quit, lock yourself in your room for a week with some drugs or porn
    or something, and just be a man and deal with the withdrawl symptoms
    (which on a physical level are probably no worse then a bad flu), on a
    mental level .. lets just say you'll find out if you have a strong mind
    or not by the end of that week.
     
  6. george

    george Newbie

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  7. Rodin

    Rodin Newbie

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    MDMA and Bupropion

    Hey all,

    I'm new to this board and in all honesty, I registered for the purpose of asking the following question.

    I started Zyban 3 weeks ago as an aid to quit smoking. Now, this weekend there's a party I would really like to attend.

    Will the combination of Zyban and MDMA give me any unwanted effects? I limit myself to one tablet and I'm fairly certain I know where it comes from. I'm taking 300 mg of Zyban every day.

    I know it sounds pretty sad but these parties happen twice a year, when I do attend, I go 'all in' - but not without being informed/knowing the possible consequences. Can anyone give me advice?

    Thanks very much
     
  8. Nicaine

    Nicaine Titanium Member

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    Most likely a risky combination, sorry to say... MDMA is an amphetamine derivative, bupropion lowers the seizure threshold. Seizure risk when combining the two is probably very high.

    P.S. read the forum rules on self-incrimination... don't admit to doing anything illegal, use terms like SWIM (Someone Who Isn't Me), etc.
     
  9. chlorination

    chlorination Newbie

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    Wellbutrin and Ecstasy

    Swim and his friend roll together and want to roll again but swim's friend has started taking Wellbutrin (for medical reasons) and I am not sure if that has any affects when the two are combined. Does anyone know what they do together if anything?
     
  10. Dr. Satan

    Dr. Satan Palladium Member

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    Re: Wellbutrin and Ecstasy

    Wellbutrin affects your dopamine which indirectly effects serotonin. Some users report it increases the roll, some say it stays the same. There have been no reported cases of adverse interactions or death from a combination of bupropion (Wellbutrin) and MDMA. Bupropion should not diminish the strength of the experience. Discontinuing the bupropion for a few days should be safe but is probably won’t make a difference, and if You do so, You should be careful not to start right up again at the full dose. Some effects of combining two drugs with stimulant effects can have an adverse effect such as a seizure or serotonin syndrome.