Clonidine is a drug that acts as an alpha-2 adrenergic agonist, the main effect being lowering blood pressure because it decreases the release of norepinephine and epinephrine (adrenalin). It is prescribed for people with high blood pressure, as well as being the main pharmacological remedy for opioid withdrawal due to its effects on the central nervous system. It helps alleviate some of the physical withdrawal symptoms such as excessive sweating and hot/cold flashes.
Introduction to Clonidine
Using ClonidineClonidine can be taken orally as prescribed for high blood pressure. Its use has also been reported in shaving soaps.
Ways of Administration
Taking Clonidine Orally
Effects of ClonidineClonidine lowers blood pressure and eases symptoms of opioid withdrawal such as hot/cold flashes and excessive sweating. Clonidine can make the user drowsy or sleepy, and these effects are more prominent if clonidine is injected. Clonidine can have some anxiolytic (anxiety reducing) effects as well by relaxing the body.
Combinations with Clonidine
Different Uses for Clonidine
Pharmacology of ClonidineClonidine is an alpha-2 adrenergic agonist. Activation of these receptors decreases release of norepinephrine and epinephrine. Clonidine lowers blood pressure.
LD50 (mg/kg) (as the hydrochloride)  :
Mice : 328 orally, 18 intravenously
Rat : 270 orally, 29 intravenously
Chemistry of Clonidine
Column 1 Column 2 Systematic (IUPAC) name: N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine Synonyms: 2-(2,6-dichloroanilino)-2-imidazoline, 2,6-dichloro-N-2-imidazolidinylidenebenzenamine, 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2), 2-[(2,6-dichlorophenyl)-imino]-2-imidazoline; ST-155, Catapres, Catapressan, Clonistada, Dixarit, Duraclon, Isoglaucon, Paracefan (hydrochloride) Molecular Formula: C9H9Cl2N3, C9H9Cl2N3.HCl Molar mass: 230.09 g/mol, 266.55 g/mol (hydrochloride) CAS Registry Number: 4205-90-7, 4205-91-8 (hydrochloride) Melting Point: 130°C, 305°C (hydrochloride) Boiling Point: no data Flash Point: no data Solubility: Freebase freely soluble in methanol, alcohol; Hydrochloride 1 g dissolves in 6 mL water (60°C), about 13 mL water (20°C), about 5.8 mL methanol, about 25 mL ethanol, about 5000 mL chloroform; soluble in absolute ethanol; slightly soluble in chloroform; practically insoluble in ether Additionnal data: none Notes: Freebase aspect : white to almost white crystals
The Dangers of Clonidine
Forms of Clonidine
Clonidine is available in 100 mcg tabs.
Legal Status of Clonidine
History of Clonidine
Popularity of Clonidine over time
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Categories: Alpha2-adrenergic receptor agonist, Imidazoline receptor agonist, Category analgesic for neuropathic pain, Category Antihypertensive