DMT

DMT is the common name for the hallucinogenic drug N,N-dimethyltryptamine, otherwise known by its scientific name 3-[2-(dimethylamino)ethyl]indole. It is also the root chemical structure for a number of other natural and synthetic hallucinogenic tryptamines, including psilocin, psilocybin, and 5-MeO-DMT, as well as the root structure for other drugs and important chemicals, such as the anti-migraine drug sumatriptan.

Using DMT

[​IMG]DMT is inactive orally without the aid of an MAOI drug as the enzyme monoamine-oxidase oxidizes orally-taken DMT too quickly for any effect to be noticed. The drug is usually therefore vaporized or snorted, or taken as part of an ayahuasca brew combining DMT with an MAOI. When combined with a pharmecutical MAOI drug, the resulting combination is called 'pharmahuasca'.

DMT is found naturally in the mammalian brain and is theorized to play an important role in thought processing, dreaming and near-death experiences, as well as meditation and out-of-body experiences such as astral-projection. When smoked, injected, or ingested in combination with a monoamine oxidase inhibitor (MAOI), DMT induces an intense hallucinogenic and psychedelic state.

Ways of administration:

Smoking


Column 1
Threshold 2 - 5 mg
Light 10 - 20 mg
Common 20 - 40 mg
Strong 40 - 60 mg

Effects of DMT

The effects of Dimethyltryptamine include physically, slightly elevated blood pressure, heart rate, pupil diameter, and rectal temperature. Mentally you go into a hallucinogenic state of mind where you feel you have entered into another world. Loss of understanding what is real and what is not.

Combinations with DMT


Different Uses for DMT


Pharmacology of DMT


Chemistry of DMT

Column 1 Column 2
Systematic (IUPAC) name: N,N-dimethyl-1H-indole-3-ethanamine
Synonyms: 3-[2-(dimethylamino)ethyl]indole, DMT
Molecular Formula: C12H16N2
Molar mass: 188.27 g/mol [2]
CAS Registry Number: 61-50-7
Melting Point: 44.6-46.8°C, 46°C (crystals from ethanol and light petroleum)
Boiling Point: 60-80°C
Flash Point: no data
Solubility: freely soluble in dilute acetic acids and dilute mineral acids; soluble in chloroform, methanol [3]
Additionnal data: pKa 8.68 (ethanol-water)
Notes: All data are old, more than 20 years, probably due to the legal status of DMT
[1]

Van Urk's reagent : blue/violet [3]

The dangers of DMT


These are the dangers common to all psychedelic drugs:

Accidental injury.
When on a psychedelic drug, it is easier to accidentally injure yourself. Also because of the disorientating and potentially delusion inspiring nature of the experience, you could be lead to inflict harm on others or yourself. People have fallen off rooftops, run into traffic, attempted to throw people off rooftops as 'sacrifices', drowned, and so on. The best way of protecting against this is to have a friend with you who is sober to look after you and handle any negative situation that might arise.

Bad trips. A bad trip is a negative psychedelic experience. It can range from a mildly negative feeling of anxiety/discomfort, to full-blown psychosis. Bad trips usually ruin a psychedelic experience for the tripper and everyone else. Most bad trips are manageable, just very uncomfortable and difficult. Some are extreme and unmanageable though. It's not uncommon for a bad trip to result in lingering psychological issues. Usually just a few days of negative emotions and anxiety. Sometimes, however, a week or so of serious anxiety, destabilized mental state and impaired functioning is possible. On very rare occasions, a month or two of severely diminished functioning, traumatized mental state, depression & crippling anxiety can occur. More information on bad trips can be found here. The best way of avoiding a bad trip is having the correct set and setting.

Permanent psychosis. Psychedelics are believed by researchers not to cause permanent psychosis, however they could trigger a latent mental illness in someone who was already predisposed to it, or make existing mental illnesses worse. If there is a history of mental illness in your family, you are more likely to be predisposed. Everyone is at some risk, however.

PTSD, anxiety disorder, depression & depersonalization. There are anecdotal reports of the trauma inflicted by some bad trips leading to depression and anxiety which while usually temporary, could potentially develop into lasting disorders. While no different to the potential of any traumatic event to cause lasting disorders, nonetheless this is a danger of psychedelic drug use.

Producing DMT

Dimethyltryptamine can be made both synthetically and extracted from various natural plant sources. The most common source is the root bark of Mimosa Hostilis, a tree native to South America. Other genera/species known to contain DMT include many Acacia sp., Desmanthus illinoensis (Illinois bundleflower), Desmodium sp., Virola sp., Arundo donax (giant reed), Phalaris sp. (canarygrasses) and Psychotria sp., especially Psychotria Vidris. It should be cautioned that many of these plant species also contain other alkaloids such as gramine, nicotine, substituted amphetamines, bufotenine and other tryptamines which can be harmful or toxic.

The process of extracting DMT from these plants usually involves crushing the plant matter to a fine powder or liquid, using a non-polar solvent such as naphtha to de-fat the extract then doing an acid/base extraction to obtain the alkaloids from the extract. Purification is not always required to achieve a psychoactive effect but is recommended.

DMT can also be synthesized via a number of different routes. While the easiest routes seem to start from tryptophan, involving decarboxylation into tryptamine followed by N,N-dimethylation to N,N-dimethyltryptamine, this is problematic because the methylation step over-methylates to a N,N,N-trimethyltryptammonium salt. This can be reduced into DMT with either lots of heat/pressure (ref: Otto Snow) or with a strong reducing agent such as Lithium Aluminum Hydride. Methylation via Eschweiler-Clarke reaction involving formic acid/formaldehyde is also problematic because reaction of tryptamines with an aldehyde in acidic solution causes a Pictet-Spengler cyclization reaction to occur, instead creating tryptoline structures.

Other routes begin from indole itself, 3-indoleacetaldehyde, 3-indoleacetic acid, and aniline via formation of a phenylhydrazine. For more, check out the rhodium archives, Tihkal and Otto Snow's works, as well as the forums.

Forms of DMT


DMT is a controlled substance (category : hallucinogen) : 21 CFR, 1308.11 [2].

DMT is illegal in most industrialized countries including the United States. However, living organisms containing DMT are not legally restricted. It is illegal naturally to try and extract the drug from these sources but they are allowed to be shipped freely around most of the modern world. Many of these preparations have other uses such as creating dyes as well as medicinal uses, such as treating burn-victims (Ref: See wiki)

Louisiana has passed Louisiana State Act 159, which outlaws certain plants and preparations of said plants, including Mimosa Hostilis, known to be used for their psychoactive properties except specifically for "aesthetic, landscaping and decorative purposes." For this reason, it may be illegal to import Mimosa root bark in that state without a legitimate reason, and companies may refuse to ship there.

United Nations


USA

DMT is a schedule I hallucinogen in the United States. Like mescaline, certain groups are allowed to use preparations of the drug for religious and ceremonial purposes.

EU


History of DMT


More DMT Sections


The latest DMT threads






References

[1] Merck Index, fifteenth edition (2013)
[2] Calculated from Atomic Weights of the Elements, 2007
[3] DMT monograph
[4] http://www.law.cornell.edu/cfr/text/21/1308.11

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