Introduction to Mescaline

[​IMG]Mescaline, 3,4,5-trimethoxyphenethylamine, is the main active phenethylamine in several cacti native to Mexico and South America including Peyote (Lophophora williamsii), San Pedro (Echinopsis pachanoi), and Peruvian Torch (Echinopsis peruviana).

It is a psychedelic hallucinogen often compared to psilocybin and LSD because it mimics serotonin and binds primarily to the 5-HT2A receptors, however mescaline is the least potent of the three. The hallucinations are similar to that of magic mushrooms, but can last significantly longer.

Peyote has been used for spiritual purposes by various tribes of Native Americans of Mexico. Though mescaline is illegal, members of the Native American Church are exempt from federal law and allowed to consume Peyote for religious purposes.

Using Mescaline

Ways of administration:

An average dose is between 200-500mg.
The effects last 4-12 hours.

Effects of Mescaline

Describe the effects, side effect, after effects.

Combinations with Mescaline

Describe which combinations are possible or known.
Describe the effects, side effect, after effects.

Different Uses for Mescaline

i.e. medical, recreative, erotic, etc.

Pharmacology of Mescaline

LD50 (mg/kg) [1] :
- Freebase
Rat : 370 intraperitoneally
- Hydrochloride
Mice : 212 intraperitoneally
Rat : 132 intraperitoneally
Guinea pig : 328 intraperitoneally

Chemistry of Mescaline

Column 1 Column 2
Systematic (IUPAC) name: 2-(3,4,5-trimethoxyphenyl)ethanamine
Synonyms: 3,4,5-trimethoxybenzeneethanamine, 3,4,5-trimethoxyphenethylamine, mezcaline
Molecular Formula: C11H17NO3, C11H17NO3.HCl (hydrochloride), (C11H17NO3)2.H2SO4.2H2O (sulfate dihydrate), C11H17NO3.H2SO4 (acid sulfate)
Molar mass: 211.26 g/mol, 247.72 g/mol (hydrochloride), 556.62 g/mol (sulfate dihydrate), 309.34 g/mol (acid sulfate) [2]
CAS Registry Number: 54-04-6, 832-92-8 (hydrochloride), 1152-76-7 (sulfate dihydrate)
Melting Point: 35-36°C, 181°C (hydrochloride), 183-186°C (sulfate dihydrate), 158°C (acid sulfate), 94°C (N-acetylmescaline)[1]
Boiling Point: 180°C @ 12 mmHg[1]
Flash Point: no data
Solubility: Freebase : soluble in alcohol, chloroform, benzene[1], acetone[3]; moderately soluble in water; practically insoluble in ether, petroleum ether[1]. Hydrochloride : soluble in water, alcohol[1][3]; insoluble in acetone, ether, hexane[3]. Sulfate dihydrate : soluble in hot water, methanol; sparingly soluble in cold water, ethanol[1]; insoluble in acetone, chloroform, ether, hexane[3].
Additionnal data: none
Notes: Freebase takes up CO2 from the air and forms a crystalline carbonate. Hydrochloride aspact : needles. Sulfate dihydrate aspect : prisms.[1]
Mescaline acetate salt has been synthetized. This salt is very soluble in water. Maybe hydrated.

Reagent test results of Mescaline

Reagent color produced picture video
Marquis Orange[3] link -
Mecke Greenish brown changing to brown[3] - -
Mandelin Green to violet to gray[3] - -
Liebermann's Black[3] - -
Froehde's Brown fading to colorless[3] - -
Vitali's Dull red Purple/dull red/brown[3] - -

The dangers of Mescaline

These are the dangers common to all psychedelic drugs:

Accidental injury. When on a psychedelic drug, it is easier to accidentally injure yourself. Also because of the disorientating and potentially delusion inspiring nature of the experience, you could be lead to inflict harm on others or yourself. People have fallen off rooftops, run into traffic, attempted to throw people off rooftops as 'sacrifices', drowned, and so on. The best way of protecting against this is to have a friend with you who is sober to look after you and handle any negative situation that might arise.

Bad trips. A bad trip is a negative psychedelic experience. It can range from a mildly negative feeling of anxiety/discomfort, to full-blown psychosis. Bad trips usually ruin a psychedelic experience for the tripper and everyone else. Most bad trips are manageable, just very uncomfortable and difficult. Some are extreme and unmanageable though. It's not uncommon for a bad trip to result in lingering psychological issues. Usually just a few days of negative emotions and anxiety. Sometimes, however, a week or so of serious anxiety, destabilized mental state and impaired functioning is possible. On very rare occasions, a month or two of severely diminished functioning, traumatized mental state, depression & crippling anxiety can occur. More information on bad trips can be found here. The best way of avoiding a bad trip is having the correct set and setting.

Permanent psychosis. Psychedelics are believed by researchers not to cause permanent psychosis, however they could trigger a latent mental illness in someone who was already predisposed to it, or make existing mental illnesses worse. If there is a history of mental illness in your family, you are more likely to be predisposed. Everyone is at some risk, however.

PTSD, anxiety disorder, depression & depersonalization. There are anecdotal reports of the trauma inflicted by some bad trips leading to depression and anxiety which while usually temporary, could potentially develop into lasting disorders. While no different to the potential of any traumatic event to cause lasting disorders, nonetheless this is a danger of psychedelic drug use.

Producing Mescaline

Mescaline Synthesis

Mescaline Extraction

Forms of Mescaline

Chemical data

History of Mescaline

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