Methoxetamine (MXE, 3-MeO-2-Oxo-PCE) is a research chemical and dissociative drug of the arylcyclohexylamines chemical class with stimulant, depressant, anti-depressant, hallucinogenic, and analgesic effects. Effects are somewhat comparable to the effects of DXM. The drug functions as both a serotonin reuptake inhibitor and an NMDA receptor antagonist, mimicking the action of both common antidepressants and dissociative drugs like ketamine, which itself behaves as a potent antidepressant.
Introduction to MethoxetamineAs a dissociative drug, methoxetamine has an interesting mechanism of action, acting both as an NMDA receptor antagonist (like many dissociative drugs) and a serotonin reuptake inhibitor, both of which contribute to the overall effects of the compound.
Ways of AdministrationMethoxetamine can be administered through a variety of different routes including oral consumption, intranasal insufflation, intramuscular injection, intravenous injection, sublingual/buccal absorption and rectal administration. Each route differs from one another in terms of the compounds time of onset, potency, and duration.
Effects of Methoxetamine
- Mild to moderate euphoria
- Antidepressant effects persisting for up to several days
- Pronounced feeling of calmness
- Anxiolysis (reduction in anxiety)
- Reflective and introspective state of mind (Cogitation)
- Insight into personal issues
- Increased clarity, detail, and/or complexity of thoughts
- Increased ability to socialize
- Increased enjoyment of music
- Spontaneous and vivid recall of latent memories
- Dissociation (separation between mind and body)
- Closed or open eyed visual hallucinations
- Loss of coordination (increasing with dose)
- Slurring of words
- Mild stimulation or body load
- Time distortion
- Increased introversion or extraversion
- Sensation of floating
- Hallucinations (Affecting all five senses)
- Urge to redose
- Short-term memory impairment, gradually resolving with abstinence
- Impairment of language processing including difficulty finding the correct words to describe thoughts
- Grandiose thinking or overconfidence
- Reduction in quality of sleep immediately following use
- Increase in anxiety at high doses
- Distressing or unwanted thoughts or insights
- Psychological dependency; risk may be greater for introverted people
- Disconnection from consensus reality with prolonged abuse
- Disorganized thoughts
- Catatonia (high doses)
- Blackouts (high doses)
- Respiratory depression (high doses & when combined with other CNS depressants)
- Death (overdose)
OralFirst effects: ~5 min
Column 1 Column 2 Light 10-20mg Common 20-40mg Strong 40-80mg
Peak begins: 20-40 mins
Peak lasts 2-4 hours
After effects 4-8 hours
InsufflationFirst effects: ~10 min
Column 1 Column 2 Light 10-20mg Common 20-50mg Strong 50-80mg
Peak begins: 20-25 mins
Peak lasts 1.5-2 hours
After effects 1-2 hours
IntramuscularFirst effects: ~5 min
Column 1 Column 2 Light 5-10mg Common 10-20mg Strong 20-30mg
Peak begins: 5-10 mins
Peak lasts 1.0-2 hours
After effects 1-2 hour
Effects are cumulative when doses are repeated. Repeated dosing too quickly (say, in less than 1.5 hours) can result in anxiety and discomfort. For those without tolerance, doses of over about 25 mg may result in a disorientated state, which is not necessarily desirable.
RectalFirst effects: ~2 min
Column 1 Column 2 Light 5-15mg Common 15-30mg Strong 30-50mg
Peak begins: 5-10 mins
Peak lasts 1.0-2 hours
After effects several hours
Plugging methoxetamine produces very quick onset coupled with a fast descent into dissociation at mid to high doses which could prove overwhelming to inexperienced users. It is also easy to accidently dose to high so starting with lower than usual dosage is advisable.
Achieving total dissociation is easier through this ROA than with oral or insufflation but considerably more nausea may be experienced. Also methoxetamine has a reputation for not dissolving in water very well. Usually it will dissolve very slowly if stirred, although some have found it impossible with some batches
Combinations with MethoxetamineMethoxetamine is a very sensitive substance on its own, let alone when combined with other drugs. Methoxetamine is known to potentiate and/or produce excessive synergy when combined with certain substances, resulting in overdose and sometimes even death.
- Cannabinoids both natural and synthetic have been known to cause uncomfortable negative side effects when combined with methoxetamine.
- Central nervous system depressants should be avoided when administering methoxetamine, as dangerous synergistic effects may result due to the combination between the two substances.
- Central nervous system stimulants should be avoided when administering methoxetamine, as the outcome tends to prove uncomfortable for the user.
- Serotonergic substance should also be avoided when administering methoxetamine, as there may be a danger of serotonin neurotoxicity to occur.
- Methoxetamine is considered to be a research chemical, thus the effects and side effects have yet to be fully establish through clinical trials, and very much likely will differ from user to user.
Different Uses for MethoxetamineMethoxetamine is a versatile substance. It is used in both solitary and social settings and may provide one of several desired results.
In a private, solitary setting, the drug may be used to increase introspection and to examine personal issues or matters of importance from a fresh perspective. Anxiety-provoking thoughts and memories may become less so under the influence of MXE, permitting difficult subject matter to be examined with greater productivity. The relatively mild psychedelic effects of the drug combined with its ability to assuage anxiety with little cognitive impairment make it a candidate for use as an adjunct to therapy in the opinion of some users. Meditation is another activity that the drug may enhance, as users often experience a strong feeling of centeredness, calmness, or peacefulness. Those desiring to use MXE for this purpose may benefit from a serene environment such as an open field.
Methoxetamine is highly effective at relieving depression quickly, often within only a few minutes, and even at doses which produce little intoxication. Users may take the drug regularly to make difficult or painful emotions or memories more manageable and less intrusive, potentially leading to psychological dependence. However, some users report improved overall functioning with regular use of small amounts of the drug.
In a Drugs-Forum Poll asking "Have you noticed non-recreational effects on mood & depression after using", as of September 14, 2014, 127 or 64.47% of respondents reported that "I have observed positive effects on mood & depression", while 42 or 21.32% reported that "I have observed negative effects on mood & depression". A further 28 or 14.21% reported "I have not observed anything other than recreational effects". 
In social settings and at low to moderate doses, MXE is useful in reducing inhibitions and enhancing conversation. Communication may become enriched and seem more authentic or meaningful. The drug produces only a moderate level of euphoria and tends not to produce violent or bizarre behavior. It complements alcohol well and is seen by some users as a natural and sensible adjunct to a night out with friends. However in excess, combining MXE with alcohol may lead to an increased risk of negative effects due to synergy between depressants.
Some users choose to consume large amounts of the drug in one session, sometimes upwards of 100mg. These amounts tend to produce a high degree of dissociation and thus both physical and mental impairment, making communication, good judgement, and normal locomotion much more difficult to achieve. Some users desire to experience the foreign mental realm that is precipitated by high doses, while other users show no such interest and instead prefer moderation.
Chemistry of MethoxetamineMethoxetamine is a member of the arylcyclohexylamine family, more specifically a derivative of ketamine, where the 2-chloro group on the phenyl ring is replaced by a 3-methoxy group, and the N-methyl group on the amine is replaced with a N-ethyl group.
Like many dissociative drugs methoxetamine is a chemical of the arylcyclohexylamine class, other chemicals in this class can be found in the table below.
Column 1 Column 2 Systematic(IUPAC) name: 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone Synonyms: Methoxetamine, MXE, 3-MeO-2-Oxo-PCE Molecular Formula: C15H21NO2, C15H21NO2.HCl (hydrochloride) Molar mass: 247.33 g/mol, 283.79 g/mol (hydrochloride)  CAS Registry Number: 1239943-76-0, 1239908-48-5 (hydrochloride) Melting Point: 244.9 °C (hydrochloride)  Boiling Point: no data Flash Point: no data Solubility: no data Additionnal data: none Notes: Hydrochloride aspect: white powder 
Column 1 Column 2 Chemical IUPAC Methoxetamine 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexanone Ketamine 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone 2-MeO-Ketamine 2-(2-Methoxyphenyl)-2-(methylamino)cyclohexanone 3-HO-PCE 3-[1-(ethylamino)cyclohexyl]phenol 3-MeO-PCE 2-(3-methoxyphenyl)-2-(ethylamino)cyclohexane 3-MeO-PCP 1-[1-(3-methoxyphenyl)cyclohexyl]-piperidine 3-MeO-PCPr 1-1[1-(3-methoxyphenyl)-N-propylcyclohexamine 3-MeO-PCPy 1-1[1-(3-methoxyphenyl)cyclohexy]pyrrolidone 4-MeO-PCP 1-[1-(4-methoxyphenyl)cyclohexyl]-piperidine Diphenidine (±)-1-(1,2-Diphenylethyl)piperidine N-Ethyl-Ketamine 2-(2-Chlorophenyl)-2-(ethylamino)cyclohexan-1-one
Reagent test results of Methoxetamine
The Dangers of Methoxetamine
RedosingRedosing Methoxetamine requires great care. This is because the effects of Methoxetamine take a long time to wear off. After the peak of the experience ends, it takes a long time to return to a baseline of zero effects. Redosing even after the peak ends can therefore have a much stronger effect than people sometimes expect at this point, because it will be added on to the previous dosage's effects which have not yet completely disappeared.
Consider this example. You insufflate 20mg of Methoxetamine at 00:00. The peak begins at 00:45, and ends at 1:30. At 2:30 you decide to re-dose 20mg, but even an hour after the peak ends your experience can still be at 50% of your original high. This brings you up to a total of 30mg by the time you come up from the re-dose, resulting in a peak 50% higher than your first. If unexpected and unwanted, this can cause a negative experience.
The best way to prevent redosing issues is stick to extremely small redoses, such as 25% of your original dose. Or you can just consider your overall dose to be an aggregate of all your dosages. Or you could just avoid redosing. Many people really do have an issue with this.
Physical Health Risks
Death from overdose has not been reported, however Methoxetamine is a research chemical so not much is known about it.
"Somebody in Sweden injected 100 mg of methoxetamine and 400 mg of MDAI ... there were cardiac problems, and the person died."
Mental Health RisksOverdose in the sense of taking so much that negative psychological effects occur can happen. Taking too much Methoxetamine can result in a bad trip involving anxiety, panic attack, paranoia, confusion & vomiting. This can range from being slightly uncomfortable to utterly terrifying and severely painful. To avoid this, increase your dosage of Methoxetamine slowly and steadily, making sure you are psychologically comfortable at a certain dosage before increasing.
If someone is experiencing a bad trip on Methoxetamine, remind them that the effects are because of a drug, remind them that the experience will end & assure them that they have not permanently damaged themselves mentally. The best tactic is to try and relax while waiting for the effects to end.
AddictionThe arylcyclohexylamines light up too many of the reward systems in the brain, with the dopamine-reuptake inhibition, the NMDA antagonism, and the µ-opioid affinity. They lend themselves to abuse and escape to fantasy
Forms of Methoxetamine
Legal Status of Methoxetamine
USAFederally methoxetamine is not considered to be an illegal substance as the analogue act only applies to schedule I and II drugs. With ketamine being a schedule III, methoxetamine would not be an illegal analogue of ketamine, however it may be treated as an analog of PCE which is a schedule I substance in the United States, thus the federal analog act would then apply.
EUUK : From 26th February 2013 MXE has become a Class B drug under the Misuse of Drugs Act.
More Methoxetamine SectionsMethoxetamine experiences: Post & read experiences with Methoxetamine.
Methoxetamine Forum: Post and read about Methoxetamine.
Research & files about Methoxetamine Upload and read research & articles on Methoxetamine.
Methoxetamine image Gallery: Post and view pictures of Methoxetamine.
Addiction Calculator: Do this small test to calculate your dependency.