Introduction to Pramiracetam

[​IMG]Pramiracetam is a lipid-soluble nootropic and a high-affinity choline uptake (HAUC) that has a similar chemical structure to Aniracetam but is 15-30 times stronger than Aniracetam. Pramiracetam is thought to increase the long term memory of users and is used in the treatment of Alzheimer's Disease. Because Pramiracetam does have a sedating effect, it is not suggested as an antidepressant.

Pramiracetam is thought to influence the Glutamate (Cholinergic) and specifically, the ACh (Acetylcholine) receptor sites, by improving reuptake and the efficiency of their channels. Pramiracetam should be taken in conjunction with a source of choline, as acetylcholine is depleted while using Pramiracetam. Pramiracetam is a cyclic derivative of GABA.[1]

Using Pramiracetam

Dosage on Pramiracetam varies greatly (ranging from 75 – 1,500mg daily) though five-hundred milligrams, three times daily, is said to be safe for most people. Pramiracetam is available in both powder and pill form, the powder seeming to be more popular because it allows the user the ability to vary doses as needed.

Those using the powder suggest putting it into orange or grape juice, resulting in helping to mask the strong flavor of the powder. It is advised that you spread your doses out to between 6-8 hours, due to the substance's half-life of 4.5 - 6.5 hours. Pramiracetam is fat soluable and does not dissolve well in liquid.

Ways of Administration

Taken orally, in pill or dissolved from its powder form.

Effects of Pramiracetam

Pramiracetam is a high-affinity choline uptake that acts possibly on a peripheral site relying on the adrenal glands. It also restores fluid to the membrane, allowing more efficient cell-signalling.[2]

Staying hydrated while using Pramiracetam is imperative because the drug causes the neurological metabolism of the brain to speed up. Without enough water intake, you can suffer from headaches, fatigue, phyrosis (heartburn) and lethargy. Pramiracetam should not be used by pregnant women; people with renal problems should consult their doctor before using.

Further, it has been noted by researchers that drugs like Pramiracetam may only work well if administered in the presence of a good supply of other hormones like estrogen or testosterone, so seniors should be cautious and seek medical advice before starting a Pramiracetam regiment.

Pharmacology of Pramiracetam

LD50 (mg/kg) (as the sulfate) [1] :
Mice : 5434 (male), 4355 (female) orally

Chemistry of Pramiracetam

Column 1 Column 2
Systematic (IUPAC) name: N-[2-(diisopropylamino)ethyl]-2-(2-oxopyrrolidin-1-yl)acetamide
Synonyms: N-[2-bis(1-methylethyl)amino]ethyl]-2-oxo-1-pyrrolidineacetamide, N-[2-(diisopropylamino)ethyl]-2-oxo-1-pyrrolidineacetamide, amacetam
Molecular Formula: C14H27N3O2, C14H27N3O2.H2SO4
Molar mass: 269.39 g/mol, 367.46 g/mol (sulfate)
CAS Registry Number: 68497-62-1, 72869-16-0 (sulfate)
Melting Point: 47-48°C (freebase monohydrate)
Boiling Point: 162-164°C @ 0.15 mmHg
Flash Point: no data
Solubility: no data
Additionnal data: none
Notes: none

Drug Combinations, "Stacks"

Those who use nootropics regulary often stack them in combinations for added benefit. Some suggested stacks are:
  • Pramiracetam + Aniracetam + Occasional Alpha GPC
  • Aniracetam + Pramiracetam + Choline CDP + Vinpocetine + Huperzine

The Effects/Dangers of Pramiracetam



Sedation, dry mouth, upset stomach/nausea and headaches


Pramiracetam is not recommended for individuals on blood thinners or those with blood coagulation problems. It is also not suggested for people who have renal (kidney) problems.

Legal Status of Pramiracetam



Pramiracetam is not considered a regulated substance and has no schedule attached to it by the FDA. Residents of the USA can buy, use and possess Pramiracetam legally.

United Kingdom

Residents of the UK can legally purchase Pramiracetam, though it remains an unregulated drug in the United Kingdom at present.


Pramiracetam is legal to use and possess in Canada


Pramiracetam is legel to possess and use, but should be bought in small quantities, according to the Austrailian government.

Other Countries


Developed in Belgium in the late 1970s by Parke Davis & Co. (now a subsidiary of Pfizer) and is currently classified as a cognitive enhancer. Many people consider it an anti-aging drug. It is also known under the name of Neupramir®. The drug's first patents were issued in Belgium in 1978 and to the U.S. in 1979. Noted to be a modification of Piracetam, Pramiracetam was synthesized in 1984 for it's anti-amnesiac potential.[4]



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[1]Merck Index, fifteenth edition (2013)

Categories: Nootropics, Racetams

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