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a-PVP

Introduction to a-PVP

a-PVP, α-Pyrrolidinopentiophenone is an alkaloid in the pyrrolidine and ketone chemical classes, functioning as a norepinephrine-dopamine reuptake inhibitor (NDRI) and acting as a stimulant on the central nervous system and cardiovascular system. a-PVP was developed in the 1960 and has been available on the research chemical market for several years now, and is used as a recreational drug.
[​IMG][/FLOAT_LEFT]

Using a-PVP

Ways of Administration

a-PVP can be administered orally, sublingually, rectally, intravenously, insufflated, and inhaled with varying doses according to the route of administration. There is a great tendency to redose with this compound which is dependent on the route of administration, care should be taken, as it is suggested not to dose more than once an hour.

Effects of a-PVP

Positive
Euphoria
Stimulation
Concentration (Dose dependent)

Negative
Anxiety
Paranoia
Psychosis
Muscle Tension
Vasoconstriction
Tachycardia

Dosing of a-PVP

Intravenous
Column 1 Column 2
Threshold < 2mg
Low 2-5mg
Moderate 5-10mg
High 10-20mg
Very High 20-30mg

Insufflation
Column 1 Column 2
Threshold 1-5mg
Low 5-20mg
Moderate 20-30mg
High 30-40mg
Very High 40-60mg
Oral
Column 1 Column 2
Threshold 1-5mg
Low 5-25mg
Moderate 25-45mg
High 45-70mg
Very High 75-100mg
Vaporized
Column 1 Column 2
Low 5-10mg
Moderate 10-2mg
High 20-40mg
Very high 40+mg
(Note: vaporization dose is very subjective due to high tendency to frequently redose. This represents one dose only.)


Chemistry of a-PVP


Column 1 Column 2
Systematic(IUPAC) name: (RS)-1-phenyl-2-(1-pyrrolidinyl)-1-pentanone
Synonyms: alpha-Pyrrolidinovalerophenone, O-2387, alpha-PVP, 1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one
Molecular Formula: C15H21NO, C15H21NO.HCl (hydrochloride)
Molar mass: 231.33 g/mol, 267.79 g/mol (hydrochloride) [2]
CAS Registry Number: 14530-33-7, 5485-65-4 (hydrochloride)
Melting Point: 161.3 °C
Boiling Point: no data
Flash Point: no data
Solubility (HCl): ~10 mg/mL in PBS (pH 7.2), ~20 mg/mL (ethanol), ~10 mg/mL (dimethylsulfoxide), ~3 mg/mL (dimethylformamide) (source ?)
Additionnal data: none
Notes: Hydrochloride aspect : white powder
[1]

MSDS Downloadable .pdf



Appearance of a-PVP

A-PVP often comes in either a white, tan, or a yellowish powder, it is also available in very small white crystals. The difference in color is unknown, however the crystals are said to have a different effect than the powder.
[​IMG][/FLOAT_LEFT] [​IMG][/FLOAT_LEFT]

United Nations

USA

A-PVP has recently become a Scheduled 1 substance under Federal Law.

EU

Finland

Illegal in Finland since 2013.

Other Countries









References


[1] α-PVP monograph
[2] Calculated from Atomic Weights of the Elements, 2007

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