Introduction to a-PVPa-PVP, α-Pyrrolidinopentiophenone is an alkaloid in the pyrrolidine and ketone chemical classes, functioning as a norepinephrine-dopamine reuptake inhibitor (NDRI) and acting as a stimulant on the central nervous system and cardiovascular system. a-PVP was developed in the 1960 and has been available on the research chemical market for several years now, and is used as a recreational drug.
Ways of Administrationa-PVP can be administered orally, sublingually, rectally, intravenously, insufflated, and inhaled with varying doses according to the route of administration. There is a great tendency to redose with this compound which is dependent on the route of administration, care should be taken, as it is suggested not to dose more than once an hour.
Effects of a-PVPPositive
Concentration (Dose dependent)
Dosing of a-PVPIntravenous
Column 1 Column 2 Threshold < 2mg Low 2-5mg Moderate 5-10mg High 10-20mg Very High 20-30mg
Column 1 Column 2 Threshold 1-5mg Low 5-20mg Moderate 20-30mg High 30-40mg Very High 40-60mg
Column 1 Column 2 Threshold 1-5mg Low 5-25mg Moderate 25-45mg High 45-70mg Very High 75-100mg
(Note: vaporization dose is very subjective due to high tendency to frequently redose. This represents one dose only.)
Column 1 Column 2 Low 5-10mg Moderate 10-2mg High 20-40mg Very high 40+mg
Chemistry of a-PVP
Column 1 Column 2 Systematic(IUPAC) name: (RS)-1-phenyl-2-(1-pyrrolidinyl)-1-pentanone Synonyms: alpha-Pyrrolidinovalerophenone, O-2387, alpha-PVP, 1-Phenyl-2-(pyrrolidin-1-yl)pentan-1-one Molecular Formula: C15H21NO, C15H21NO.HCl (hydrochloride) Molar mass: 231.33 g/mol, 267.79 g/mol (hydrochloride)  CAS Registry Number: 14530-33-7, 5485-65-4 (hydrochloride) Melting Point: 161.3 °C Boiling Point: no data Flash Point: no data Solubility (HCl): ~10 mg/mL in PBS (pH 7.2), ~20 mg/mL (ethanol), ~10 mg/mL (dimethylsulfoxide), ~3 mg/mL (dimethylformamide) (source ?) Additionnal data: none Notes: Hydrochloride aspect : white powder
MSDS Downloadable .pdf
Appearance of a-PVPA-PVP often comes in either a white, tan, or a yellowish powder, it is also available in very small white crystals. The difference in color is unknown, however the crystals are said to have a different effect than the powder.
Legal Status of a-PVP
USAA-PVP has recently become a Scheduled 1 substance under Federal Law.
FinlandIllegal in Finland since 2013.
 α-PVP monograph
 Calculated from Atomic Weights of the Elements, 2007
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