Clonidine Printable Version

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Clonidine is a drug that acts as an alpha-2 adrenergic agonist, the main effect being lowering blood pressure because it decreases the release of norepinephine and epinephrine (adrenalin). It is prescribed for people with high blood pressure, as well as being the main pharmacological remedy for opioid withdrawal due to its effects on the central nervous system. It helps alleviate some of the physical withdrawal symptoms such as excessive sweating and hot/cold flashes.

Introduction to Clonidine

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Using Clonidine

Clonidine can be taken orally as prescribed for high blood pressure. Its use has also been reported in shaving soaps.

Ways of Administration

Taking Clonidine Orally

Snorting Clonidine

Injecting Clonidine

Plugging Clonidine

Effects of Clonidine

Clonidine lowers blood pressure and eases symptoms of opioid withdrawal such as hot/cold flashes and excessive sweating. Clonidine can make the user drowsy or sleepy, and these effects are more prominent if clonidine is injected. Clonidine can have some anxiolytic (anxiety reducing) effects as well by relaxing the body.

Combinations with Clonidine

Different Uses for Clonidine

Pharmacology of Clonidine

Clonidine is an alpha-2 adrenergic agonist. Activation of these receptors decreases release of norepinephrine and epinephrine. Clonidine lowers blood pressure.

LD50 (mg/kg) (as the hydrochloride) [1] :
Mice : 328 orally, 18 intravenously
Rat : 270 orally, 29 intravenously

Chemistry of Clonidine

Column 1 Column 2
Systematic (IUPAC) name: N-(2,6-dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
Synonyms: 2-(2,6-dichloroanilino)-2-imidazoline, 2,6-dichloro-N-2-imidazolidinylidenebenzenamine, 2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2), 2-[(2,6-dichlorophenyl)-imino]-2-imidazoline; ST-155, Catapres, Catapressan, Clonistada, Dixarit, Duraclon, Isoglaucon, Paracefan (hydrochloride)
Molecular Formula: C9H9Cl2N3, C9H9Cl2N3.HCl
Molar mass: 230.09 g/mol, 266.55 g/mol (hydrochloride)
CAS Registry Number: 4205-90-7, 4205-91-8 (hydrochloride)
Melting Point: 130°C, 305°C (hydrochloride)
Boiling Point: no data
Flash Point: no data
Solubility: Freebase freely soluble in methanol, alcohol; Hydrochloride 1 g dissolves in 6 mL water (60°C), about 13 mL water (20°C), about 5.8 mL methanol, about 25 mL ethanol, about 5000 mL chloroform; soluble in absolute ethanol; slightly soluble in chloroform; practically insoluble in ether
Additionnal data: none
Notes: Freebase aspect : white to almost white crystals
[1]

The Dangers of Clonidine

Danger 1

Danger 2

Danger 3

Danger 4

Producing Clonidine

Forms of Clonidine

Tabs

Legal Status of Clonidine

United Nations

USA

EU

Other Countries

History of Clonidine

Popularity of Clonidine over time

Clonidine
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References


[1]Merck Index, fifteenth edition (2013)