Sertraline Printable Version

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  jtc3889
  on May 7, 2013
  
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  on Nov 16, 2021

Sertraline is a selective serotonin reuptake inhibitors or SSRI, which operate by increasing levels of seratonin in the brain. Sertraline is used to treat major depressive, obsessive compulsive (OCD), panic, post traumatic stress, premenstrual dysphoric disorder (PMDD) and social anxiety disorders. It differs from other antidepressants mostly in side effects, which include diarrhea, nausea, trembling, sexual dysfunction and weight gain. In 2013 it was the most used antidepressant in the United States. The starting dose is 50mg but some people are prescribed up to 200mg. [1]

Introduction to Sertraline

Using Sertraline

Ways of Administration

Effects of Sertraline

Combinations with Sertraline

Different Uses for Sertraline

Pharmacology of Sertraline

Chemistry of Sertraline

Column 1 Column 2

Systematic(IUPAC) name: (1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-naphtalen-1-amine

Synonyms: CP-51974-1, Lustral, Zoloft (hydrochloride)

Molecular Formula: C₁₇H₁₇Cl₂N

Molar mass: 306,23 g/mol.

CAS Registry Number: 79617-96-2, 79559-97-0 (hydrochloride)

Melting Point: 243-245°C (hydrochloride)

Boiling Point: no data

Flash Point: no data

Solubility: hydrochloride (room temperature, mg/mL) : water 3.8, 0.1N HCl 0.51, 0.1N NaOH 0.002, ethanol 15.7, isopropanol 4.3, chloroform 110, acetone 1.1, DMF 88, DMSO 147, ethyl acetate 0.20, acetonitrile 0.85, methanolic 0.1N HCl 47, chloroform/methanol 1:1 134

Additionnal data: pKa (ethanol/water 1:1 v/v) 8.5, density 1.37 (hydrochloride)

Notes: none

[1]

Column 1	Column 2
Systematic(IUPAC) name:	(1S,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-naphtalen-1-amine
Synonyms:	CP-51974-1, Lustral, Zoloft (hydrochloride)
Molecular Formula:	C₁₇H₁₇Cl₂N
Molar mass:	306,23 g/mol.
CAS Registry Number:	79617-96-2, 79559-97-0 (hydrochloride)
Melting Point:	243-245°C (hydrochloride)
Boiling Point:	no data
Flash Point:	no data
Solubility:	hydrochloride (room temperature, mg/mL) : water 3.8, 0.1N HCl 0.51, 0.1N NaOH 0.002, ethanol 15.7, isopropanol 4.3, chloroform 110, acetone 1.1, DMF 88, DMSO 147, ethyl acetate 0.20, acetonitrile 0.85, methanolic 0.1N HCl 47, chloroform/methanol 1:1 134
Additionnal data:	pKa (ethanol/water 1:1 v/v) 8.5, density 1.37 (hydrochloride)
Notes:	none

The Dangers of Sertraline

Physical Health Risks

<Physical Problem 1 - Please Identify and Add Others As Necessary>

<Physical Problem 2 - Please Identify and Add Others As Necessary>

Overdose

Reported Deaths

Mental Health Risks

<Mental Health Risk 1 - Please Identify and Add Others As Necessary>

<Mental Health Risk 2 - Please Identify and Add Others As Necessary>

Side Effects

Addiction

Physical Addiction

Mental Addiction

ProducingSertraline

Forms of Sertraline

Legal Status of Sertraline

United Nations

USA

EU

Other Countries

History of Sertraline

More Sertraline Sections

Sertraline

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References

^Preskorn, S. H., & Lane R. M., (1995) Sertraline 50 mg daily: the optimal dose in the treatment of depression. Int Clin Psychopharmacol. 10(3):129-41.

[1]Merck Index, fifteenth edition (2013)