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Access denied "Not for Human Consumption": A Review of Emerging Designer Drugs (2014)
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Vol. 34, Issue 7, Pages 745–757, Jul.2014

Megan E. Musselman, Jeremy P. Hampton

Abstract:
Synthetic, or “designer” drugs, are created by manipulating the chemical structures of other psychoactive drugs so that the resulting...

See also Piperazines Documents  Phenethylamines Documents  Mephedrone & other Beta-ketones Documents  Cannabinoids Documents 
 
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Access denied "Research chemicals": tryptamine and phenethylamine use among high-risk youth (2008) 5 *
Substance Use and Misuse 2008;43(3-4):389-402

Sanders B, Lankenau SE, Bloom JJ, Hathazi D.

Tryptamines and phenethylamines are two broad categories of psychoactive substances with a long history of licit and illicit use. Profiles of users of recently emerging tryptamines and phenethylamines...

See also Drug Use Documents 
 
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Submitted by Jatelka Find all entries from this user
19-09-2008
311.05 Kbytes Hits 194
Access denied α-Thienylaminoalkanes
F. F. Blicke, J. H. Burckhalter
J. Am. Chem. Soc., 1942, 64 (3), pp 477–480
 
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Submitted by Anonymous Find all entries from this user
03-03-2011
447.81 Kbytes Hits 49
Keywords: methiopropamine
Access denied (+/-)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-Aminopropanone (ALEPH-2), a Novel Putative Anxiolytic Agent Lacking Affinity for Benzodiazepine Receptors and 5-HT1A Receptors (Reyes-Perada et al, 1996)
Originally published in The Archives of Pharmacology

The mechanism of action and anxiolytic properties of ALEPH-2 are discussed
 
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Submitted by Jatelka Find all entries from this user
09-05-2007
635.39 Kbytes Hits 117
Keywords: anxiolytic benzodiazepines aleph-2
Access denied 1,3-Dimethylamylamine (DMAA) in supplements and geranium products: natural or synthetic?
1,3-Dimethylamylamine (DMAA) is a stimulant existing in various pre-workout supplements and often labelled as part of geraniumplants. The safety and origin of DMAA in these supplements is the subject of intense debate. In this study, the enantiomericand diastereomeric ratios of two different known...

See also Stimulants in general Documents 
 
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Submitted by davestate Find all entries from this user
20-07-2012
339.08 Kbytes Hits 33
Access denied 1-(4-Methylphenyl)-2-pyrrolidin-1-yl-pentan-1-one (Pyrovalerone) analogues: a promising class of monoamine uptake inhibitors
Meltzer PC, Butler D, Deschamps JR, Madras BK

Abstract: Dopamine, serotonin, and norepinephrine are essential for neurotransmission in the mammalian system. These three neurotransmitters have been the focus of considerable research because the modulation of their production and their interaction...
 
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Submitted by Gradient Find all entries from this user
28-07-2009
434.00 Kbytes Hits 139
Access denied 1-Aminomethylbenzocycloalkanes: Conformationally Restricted Hallucinogenic Phenethylamine Analogues as Functionally Selective 5-HT2A Receptor Agonists
J. Med. Chem. 2006, 49, 5794-5803
Thomas H. McLean, Jason C. Parrish, Michael R. Braden, Danuta Marona-Lewicka, Alejandra Gallardo-Godoy, and David E. Nichols

A series of conformationally restricted analogues of the hallucinogenic phenethylamine 1 (2,5-dimethoxy-
4-bromophenethylamine, 2C-B)...
 
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Submitted by Anonymous Find all entries from this user
05-11-2010
194.33 Kbytes Hits 22
Access denied 11C-WIN 35,428 for detecting dopamine depletion in mild Parkinson's disease
Madras BK. Annals of neurology. 1994;35(3).

In the September 1993 issue of Annals. an article entitled “Positron Emission Tomographic Imaging of the Dopamine Transporter with ”C-WIN 35,428 Reveals Marked Decline in Mild Parkinson’s Disease” (Frost et al, Ann Neurol 1993; 14:423) was printed as...
 
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Submitted by staples Find all entries from this user
21-09-2009
253.12 Kbytes Hits 20
Keywords: win-35428
Access denied 970 Million Druglike Small Molecules for Virtual Screening in the Chemical Universe Database GDB-13
Paper from American Chemical Society, retrieved for this news thread (https://drugs-forum.com/forum/showthread.php?t=93888) The paper is two pages. The .zip file contains the paper as two separate .gif files.

One of the most important chemical issues in drug discovery is innovation, in...
 
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Submitted by Johan73 Find all entries from this user
07-07-2009
283.04 Kbytes Hits 56
Keywords: chemistry drug drug-research research-chemicals
Access denied A 3-year review of new psychoactive substances in casework (2014)
Forensic Science International, Vol. 243, October 2014, Pages 55–60

Simon Elliott, Julie Evans

Abstract:
Following the initial popularity of mephedrone (4-methylmethcathinone) there has been a stream of new "recreational drugs" entering the global market. The lack of clinical studies on the...
 
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Access denied A general approach to the screening and confirmation of tryptamines and phenethylamines by mass spectral fragmentation (B. Chena et al. 2007)
Talanat 74 (2008) 512-517

Authors: Bo-Hong Chena, Ju-Tsung Liu, Wen-Xiong Chena, Hung-Ming Chena, Cheng-Huang Lin

See also Drug Testing Documents 
 
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Submitted by ThirdEyeFloond Find all entries from this user
18-01-2008
483.32 Kbytes Hits 95
Keywords: phenethylamines tryptamines
Access denied A Novel (Benzodifuranyl)aminoalkane with Extremely Potent Activity at the 5-HT2A Receptor
Parker MA, Marona-Lewicka D, Lucaites VL, Nelson DL, Nichols DE.

A major focus of our research for a number of years has been to understand the structure-activity relationship (SAR) of classical hallucinogens and their derivatives, the pharmacological action of which is believed to be...

See also Phenethylamines Documents 
 
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Submitted by Gradient Find all entries from this user
10-08-2010
37.37 Kbytes Hits 34
Access denied A regulatory perspective on the abuse potential evaluation of novel stimulant drugs in the United States (2014)
Neuropharmacology, Available online 12/Apr/2014, In Press, Corrected Proof

Silvia N. Calderon, Michael Klein

Abstract:
In the United States of America (USA), the abuse potential assessment of a drug is performed as part of the safety evaluation of a drug under development, and to evaluate if...
 
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Submitted by Behrang Find all entries from this user
23-07-2014
351.04 Kbytes Hits 17
Access denied A report of an outbreak of toxicity from a novel drug of abuse: ERIC-3 (2012)
Emergency Medicine Journal (2012). doi:10.1136/emermed-2012-201631

Haig SD, Kelly C, Morden C

ABSTRACT
Background Novel drugs of abuse are becoming more common in the UK, and they represent particular difficulties in management. We present a case series of toxicity due to a novel substance...
 
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Submitted by Calliope Find all entries from this user
27-09-2012
64.22 Kbytes Hits 87
Access denied A study about the synthesis of seven-membered-ring analogues of ketamine (2014)
Research on Chemical Intermediates, Published online: Sep.2014

Abolghasem Moghimi, Mohammad Reza Shahdadi, Sajjad Keshipour, Morteza Sadeghzadeh

Abstract:
Synthesis of seven-membered ring analogues of ketamine was studied with two strategies. In the first approach a sequence of five...

See also Ketamine Documents  Dissociatives Documents 
 
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Submitted by Behrang Find all entries from this user
25-09-2014
510.10 Kbytes Hits 25
Access denied ACMD advice on O-desmethyltramadol
ACMD letter to home secretary recommending the scheduling of o-desmethyltramadol to class B, along with notification that ACMD will review tramadol itself in Dec 2012

See also Opium, Opiate & Opioids Documents  Law Documents 
 
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Submitted by davestate Find all entries from this user
01-11-2012
77.64 Kbytes Hits 29
Access denied ACMD avice on methoxetamine and arylcyclohexylamines
ACMD advice on legislation to control methoxetamine and proposals for a generic "analogue" law for arylcyclohexylamines

See also Law Documents  Dissociatives Documents 
 
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Submitted by davestate Find all entries from this user
21-11-2012
427.39 Kbytes Hits 55
Access denied ACMD Report - NBOMe compounds: A review of the evidence of use and harm
Report by the UK Advisory Council on the Misuse of Drugs
28th November 2013

See also Phenethylamines Documents 
 
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Submitted by Phenoxide Find all entries from this user
30-11-2013
417.77 Kbytes Hits 28
Keywords: n-benzylphenethylamines psychedelic phenethylamines chemicals 25i-nbome 25d-nbome 25c-nbome
Access denied ACMD Report on Benzofuran Compounds
The ACMD's consideration on Benzofurans and related compounds

See also Law Documents 
 
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Submitted by Seaquake Find all entries from this user
30-11-2013
452.18 Kbytes Hits 8
Keywords: acmd benzofuran classification
Access denied ACMD request for temporary class drug order to control novel psychoactive substances (May 2013)
Opening paragraph, from Prof. Les Iversen (chair of the ACMD) to the UK Home Office:

I am writing to formally request that you consider laying a temporary class drug order (TCDO) pursuant to section 2A of the Misuse of Drugs Act 1971 on the following two groups of novel psychoactive substances...

See also Phenethylamines Documents  Law Documents 
 
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Submitted by kimotag Find all entries from this user
05-06-2013
542.08 Kbytes Hits 22
Keywords: legality chemicals acmd 6-it 6-apdb 6-apb 5-it 5-apdb 5-apb 25i-nbome 25d-nbome 25c-nbome 25b-nbome
Access denied Acute Neurochemical and Behavioral Effects of Stereoisomers of 4-Methylaminorex in Relation to Brain Drug Concentrations 4 *
4-Methylaminorex is a stimulant drug of abuse that exists as four stereoisomers: cis-4R,5S, cis-4S,5R, trans-4S,5S, and trans-4R,5R. These isomers have previously been shown to differ markedly in various respects. In the present study we assessed the
effects of the isomers of 4-methylaminorex...
 
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Submitted by Shampoo Find all entries from this user
10-01-2012
397.68 Kbytes Hits 20
Access denied Acute toxicity associated with the recreational use of the ketamine derivative methoxetamine
David M. Wood & Susannah Davies & Malgorzata Puchnarewicz & Atholl Johnston & Paul I. Dargan

Abstract
PURPOSE:
Long-term regular use of ketamine has been reported to be associated with severe symptomatic urinary tract problems. Methoxetamine, an arylcyclohexylamine derivative of ketamine, is...

See also Dissociatives Documents 
 
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Submitted by Gradient Find all entries from this user
25-04-2012
101.58 Kbytes Hits 26
Keywords: methoxetamine mxe
Access denied Advances in Pharmacology, Vol. 69: Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse - Chapter 15: Bath Salts, Mephedrone, and Methylenedioxypyrovalerone as Emerging Illicit Drugs That Will Need Targeted Therapeutic Intervention (2014)
Advances in Pharmacology, Vol. 69: Emerging Targets & Therapeutics in the Treatment of Psychostimulant Abuse

Edited by Linda P. Dwoskin

ISBN: 9780124201187

http://www.sciencedirect.com/science/bookseries/10543589/69

--------------------

See also Mephedrone & other Beta-ketones Documents 
 
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Submitted by Behrang Find all entries from this user
14-10-2014
1.58 Mbytes Hits 33
Access denied Aminoindanes – the next wave of legal highs?
Due to its closed ring system, 2-aminoindane is a conformationally rigid analogue of amphetamine. Internet websites offering synthetic compounds as ‘research chemicals’ have recently been advertising 5,6-methylenedioxy-2-aminoindane (MDAI), 5, 6-methylenedioxy-N-methyl-2-aminoindane (MDMAI),...  
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Submitted by ramskip Find all entries from this user
27-09-2012
76.67 Kbytes Hits 37
Access denied An analysis of legal highs-do they contain what it says on the tin? (2011)
Drug Test Anal. 2011 May 19

Baron M, Elie M, Elie L.

In recent years the availability of so-called legal highs over the Internet has hugely increased. Numerous online legal-high retailers market a broad variety of products which are advertised as research chemicals, bath salts, or plant...

See also Piperazines Documents 
 
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Submitted by Jatelka Find all entries from this user
04-06-2011
992.49 Kbytes Hits 100
Access denied An Opioid Agonist that Does Not Induce Opioid Receptor-Arrestin Interactions or Receptor Internalization
C. E. Groer, K. Tidgewell, R. A. Moyer, W. W. Harding, R. B. Rothman, T. E. Prisinzano, and L. M. Bohn

G protein-coupled receptor desensitization and trafficking are important regulators of opioid receptor signaling that can dictate overall drug responsiveness in vivo. Furthermore, different...

See also Opium, Opiate & Opioids Documents 
 
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Submitted by Gradient Find all entries from this user
27-09-2009
487.84 Kbytes Hits 39
Access denied An Overview of New Psychoactive Substances and the Outlets Supplying Them
An Overview of New Psychoactive Substances and the Outlets Supplying Them

Commissioned by the National Advisory Committee on Drugs (NACD)

Authors
Cathy Kelleher, Rachel Christie, Kevin Lalor, John Fox, Matt Bowden and Cora O’Donnell, Centre for Social and Educational Research, Dublin...
 
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Submitted by Terrapinzflyer Find all entries from this user
28-06-2011
1.35 Mbytes Hits 66
Access denied Analysis of First and Second Generation Legal Highs for Synthetic Cannabinoids and Synthetic Stimulants by UPLC/ToF
Various “legal high” products were tested for synthetic cannabinoids
and synthetic stimulants to qualitatively determine the active
ingredient(s). Ultra-performance liquid chromatography with accurate
mass time-of-flight mass spectrometry (UPLC–TOF) was used
to monitor the non-biological...
 
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Submitted by stryder09 Find all entries from this user
05-07-2012
363.99 Kbytes Hits 41
Access denied Analysis of new designer drugs and common drugs of abuse in urine by a combined targeted and untargeted LC-HR-QTOFMS approach (2014)
Analytical and Bioanalytical Chemistry, Vol. 406, Issue 18, Jul/2014, Pages 4425-4441

Michael Paul, Josef Ippisch, Christian Herrmann, Susanne Guber, Wolfgang Schultis

Abstract:
The development of a liquid chromatography high-resolution mass spectrometry quadrupole-time-of-flight...

See also Drug Testing Documents 
 
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Submitted by Behrang Find all entries from this user
24-07-2014
1.25 Mbytes Hits 7
Access denied Analysis of NRG ‘legal highs’ in the UK: Identification and formation of novel cathinones
Simon D. Brandt, Sally Freeman, Harry R. Sumnall, Fiona Measham and Jon Colee.


Abstract:
A large number of cathinone derivatives have shown a wide range of bioactive properties, attracting great interest from communities associated with pharmaceutical research. Some of these derivatives have...
 
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Submitted by catseye Find all entries from this user
26-01-2011
177.25 Kbytes Hits 101
Keywords: cathinones mephedrone naphyrone nrg-1 nrg-3
Access denied Analysis of psychoactive and intoxicating substances in legal highs
Annals of Agricultural and Environmental Medicine 2012, Vol 19, No 2, 309-314
PubMed PMID: 22742807

Wioletta Żukiewicz-Sobczak 1, Jacek Zwoliński 1, Jolanta Chmielewska-Badora 1, Ewelina Krasowska1, Jacek Piątek 1, Paweł Sobczak 2, Andrzej Wojtyła 3, Emilia Fornal 4,5, Andrzej Kuczumow 4,...
 
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Submitted by YIPMAN Find all entries from this user
20-07-2012
305.68 Kbytes Hits 29
Keywords: boosters psychoactive highs drugs designer
Access denied ANNUAL REPORT ON THE HOME OFFICE FORENSIC EARLY WARNING SYSTEM (FEWS) A SYSTEM TO IDENTIFY NEW PSYCHOACTIVE SUBSTANCES IN THE UK
This report provides a background to the Home Office Forensic Early Warning System (FEWS). FEWS was set up to identity New Psychoactive Substance (NPS) more promptly to enable Her Majesty’s Government to take action before a harmful substance takes a foothold in the UK. FEWS is part of the...

See also Law Documents 
 
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Submitted by davestate Find all entries from this user
07-06-2012
119.99 Kbytes Hits 39
Access denied Anti-nociceptive effects in N-substituted cyclohexylmethylbenzamides.
Br J Pharmacol. 1973 September; 49(1): 158P–159P.
R. T. BRITRAIN*, D. N. KELLETT, M. L. NEAT and R. STABLES

In the mouse, certain N-substituted cyclohexylmethylbenzamides markedly inhibited
writhing induced by phenylquinone and the nociceptive responses to being placed on
a hot plate (550 C)...

See also Opium, Opiate & Opioids Documents 
 
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Submitted by davestate Find all entries from this user
26-09-2012
200.66 Kbytes Hits 17
Keywords: ah7921 ah-7921
Access denied Arylalkylamine drugs of abuse: an overview of drug discrimination studies (1999)
Pharmacol Biochem Behav. (javascript:AL_get(this, 'jour', 'Pharmacol Biochem Behav.') 1999 Oct;64(2):251-6

Glennon RA...
 
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Submitted by Jatelka Find all entries from this user
27-01-2008
163.12 Kbytes Hits 82
Keywords: arylalkylamines indolealkylamines phenylalkylamines
Access denied Behavioural Effects of the Putative Anxiolytic (+/-)-1-(2,5-dimethoxy-4-ethylthiophenyl)-2-Aminopropanone (ALEPH-2) in Rats and Mice (1996)
Pharmacology Biochemistry and Behaviour 1996 Jun;54(2):355-61

Scorza, M.C. ; Reyes-Parada, M. ; Silveira, R. ; Viola, H. ; Medina, J.H. ; Viana, M.B. ; Zangrossi, H. ; Graeff, F.G.

Abstract
Behavioral effects of the phenethylamine derivative...
 
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Submitted by Jatelka Find all entries from this user
09-05-2007
744.33 Kbytes Hits 68
Keywords: aleph-2
Access denied Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-nenzyl-nitro-benzimidazolen
Benzimidazol-Derivate und verwandte Heterocyclen III. Synthese von 1-Aminoalkyl-2-nenzyl-nitro-benzimidazolen

A. von Hunger, J. Kebrle, A. Rossi, K. Hoffmann

Helvetica Chimica Acta (1960), Volume XLIII, No. 132

Abstract: The synthesis of a series of...

See also Deutsches Dokumente (German)  Opium, Opiate & Opioids Documents 
 
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Submitted by Phenoxide Find all entries from this user
30-04-2012
1.64 Mbytes Hits 39
Keywords: chemicals opioid metonitazene etonitazene nitazene clonitazene
Access denied Bioanalysis of new designer drugs (2010)
Bioanalysis. 2010 May;2(5):965-79.

Wohlfarth A, Weinmann W

Since the late 1990s the illicit drug market has undergone considerable change: along with the traditional drugs of abuse that still dominate, more than 100 psychotropic substances designed to bypass controlled substances...

See also Drug Testing Documents 
 
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Submitted by Jatelka Find all entries from this user
19-12-2010
1.43 Mbytes Hits 130
Access denied Biochemical and Behavioral Characterization of Novel Methylphenidate Analogs
As part of a project to develop treatment agents for cocaine abuse, ()-threo-methylphenidate (TMP) and 11 analogs were characterized biochemically and behaviorally to assess their
potential as anti-cocaine medications. The compounds contained aryl and/or nitrogen substitutions, and/or replacement...
 
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Submitted by davestate Find all entries from this user
13-12-2012
323.47 Kbytes Hits 68
Keywords: 4-dichloro-methylphenidate
Access denied Biological activity in compounds possessing thiophen rings
J Med Pharm Chem. 1959 Dec;1:507-64.
MARTIN-SMITH M, REID ST.
 
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Submitted by Anonymous Find all entries from this user
03-03-2011
2.94 Mbytes Hits 23
Keywords: methiopropamine
Access denied Buying ‘legal’ recreational drugs does not mean that you are not breaking the law
QJM. 2010 Jul 30.
Ramsey J, Dargan PI, Smyllie M, Davies S, Button J, Holt DW, Wood DM.
PMID: 20675395

Summary
Background: Recreational drug use in the UK is
common; sources of recreational drugs are changing, with increasing purchase of legal highs from the Internet. Previous studies have...
 
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Submitted by Anonymous Find all entries from this user
06-08-2010
61.58 Kbytes Hits 34
 



 
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