Atypical or second-generation antipsychotics (SGAs), including aripiprazole (ARI) and olanzapine (OLA), are drugs of choice for schizophrenia treatment and are effective against delusions, hallucinations, and extrapyramidal adverse events.
- Journal Name:
- Int. J. Mol. Sci. 2022, 23, 8292
- Publication Date:
- 27 July 2022
- PMID:
- 35955425
Oxidative stress, an imbalance between oxidants and antioxidants, can result in liver inflammation, proliferation, and metabolic derangements. ARI protects liver cells from acute oxidative stress better than OLA.
Antipsychotic Drug Aripiprazole Protects Liver Cells from Oxidative Stress
Only aripiprazole, but not olanzapine, protects liver cells against oxidative stress.