Modafinil affects mood, but not cognitive function, in healthy young volunteers

There were no significant differences between the three treatment groups on any of the cognitive tests used in this study. There was a significant post-treatment change in the factor measuring somatic anxiety and in individual ratings of shaking , palpitations, dizziness, restlessness, muscular tension, physical tiredness and irritability, which was mainly due to significantly higher ratings of somatic anxiety in the 100 mg group compared with the other two groups. Further changes in mood were revealed after the stress of cognitive testing, with the 100 mg group showing greater increases in the psychological anxiety and the aggressive mood factors (as measured from the Bond and Lader scales).