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Oral use Sublingual 2C-E? Alternative routes for harnessing a difficult substance

Discussion in 'Phenethylamines' started by JDreaming, Jul 27, 2007.

  1. Jul 27, 2007 #1
    JDreaming

    JDreaming R.I.P. Gold Member R.I.P.

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    I'm getting a little tired of SWIM right now so let me try to explain my question as best as possible...

    My pet hippopotamus (who happens to have generally human-like dose-response characteristics with all drugs) recently had the occasion to test a dose of 15 miligrams of 2,5-Dimethoxy-4-ethyl-phenethylamine for the first time. While I have not completely processed my hippo's trip report for him yet, the gist of the experience was this: The hippo had been warned he was dealing with a rewarding but difficult substance, and it certainly was that. The first half of the peak was severely marred by nausea and body load, and my hippopotamus frankly could not keep the powder down in his stomach.

    While hippo is not ready to comment just yet on the synaesthetic effects (which were my main attraction to this compound, and the reason I wanted to test it on my hippo- and synaesthesia definately did occur) I can't help but wonder if there might be a way to reduce the difficulty of the come-up when testing this. I was thinking maybe next time I'd have my hippo try sublingually absorbing the powder, dissolved into water, and spitting it out, to attempt to harness the synaesthetic space without once again inducing the awful temporary nausea that my hippo has just experienced.

    Has anyone tried this on their test subjects, or any other alternate route of administration for 2C-E that they found effective? Does this compound absorb well enough if held in the mouth and spit out to produce a rewarding trip experience, and does it reduce the nausea and overall harshness while coming up? I am not willing to inject my hippo with anything, and snorting any sort of 2-C would obviously be a bad idea. But I would like to find a way of putting this strange synaesthetic compound into a test animal's brain without traumatizing his stomach or body in the process any more than necessary.
     
    Last edited by a moderator: Nov 28, 2010
  2. Jul 27, 2007 #2
    Felonious Skunk

    Felonious Skunk Gold Member

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    Have heard that splitting the dose in two and taking them 30 minutes apart may reduce the nausea.
     
  3. Jul 28, 2007 #3
    grandbaby

    grandbaby Titanium Member

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    Some clams have been known to put a dose of a nausea-inducing phen into a large drink and to sip the drink slowly over an hour or so, to spread out absorption. No nausea has been observed, and it should be noted that these are generally fairly queasy clams.
     
  4. Jul 28, 2007 #4
    RunRedFox

    RunRedFox Gold Member

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    in swims experienc 2c-e absorbs fairly quickly. I has vommited most times while using 2c-e but the vommiting usually ends the nausea and begins the trip. I has notived with multiple PEA's that he gets nausea when he is moving around alot. when he is still he doesnt experience this as much. also I has heard marijuana helps with nausea with the more traditional hallucinegens so swims assumes this may be true of research chemicals. Its worth a try. If You does try this, I would like to hear a report of how it effected the nausea.
     
  5. Jul 28, 2007 #5
    Nagognog2

    Nagognog2 Iridium Member

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    Puking on mescaline and/or peyote (another PEA) is considered normal. Many Native folk consider it to be when the journey begins. Like purging out the old to welcome the new.

    Some claim this is not from the mescaline in peyote, but other alkaloids. Bongo begs to disagree - as he puked strongly on pure mescaline.
     
  6. Aug 6, 2007 #6
    JDreaming

    JDreaming R.I.P. Gold Member R.I.P.

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    Thanks for the input, guys. I realize with many powerful phenthylamines, nausea can be a necessary part of the trip experience, connected to the feeling of renewal and rebirth that comes as the peak begins... but the nausea from this compound was a bit intense for my hippo. Splitting doses or sipping them slowly seem like good suggestions.

    Sinced it seemed like 2C-E has not been sublingualed often before, I tested it on my hippo yesterday. Another 15 mg pill capsule was selected, emptied out into a shot glass, and mixed with a small amount of purified water. Powder dissolved very slowly and required much stirring. Hippo then administered it under his tongue for 25 minutes before spitting it out and washing out his mouth. Nausea and discomfort was diminished very significantly, with no vomiting at any time. But the hallucinogenic effect diminished somewhat as well. Experience peaked a little over an hour after spitting the substance out, reaching a moderate +2 (as opposed to a +3 the first time, taking the same dose by swallowing). Back at baseline except for slight pupil dilation at T+7 hours (took 9.5 hours to reach the same point at the same dose in the previous experiment.) There were lighter, more selective visuals, but still a definite hallucinogenic effect.

    Conclusion: Sublingual application of 2C-E is effective, but dosage may need to be increased slightly to compensate for the diminished hallucinogenic effect. A recommended experiment for anyone interested in this compound whose test animals might have sensitive stomachs. SWIM's next experiment will be to dissolve it in alcohol, which I realize will probably transmit a lot more cleanly than water.

    I have concluded the first trip report for testing 2C-E and will publish it in a future post along with various other first psychedelic trips from my test subjects.
     
    Last edited: Aug 6, 2007
  7. Aug 6, 2007 #7
    Mona Lisa

    Mona Lisa Gold Member

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    There's always the back door :crazy (though with doses halved accordingly).

    If taken orally (Salvia), apparently it can also help to brush under ones tongue and base of mouth, then subsequently rinse with listerine to enhance oral absorption. Would have thought the same would apply here.
     
    Last edited: Aug 6, 2007
  8. Sep 2, 2010 #8
    darkbreed

    darkbreed Silver Member

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    Well from My last couple experiences, 2c's work fine sublingual, he tested both 2c-i and 2c-e last couple days , not intentionally for tripping, but rather for tasting the chemicals after measuring doses and having some powder stuck left on the knife and tinfoil used. He licked this, in extremely small dosages, between 2-4mg, and got effects out of it (read his last trip report in the experiences section on 2c-i ).

    Of course, he didnt actually try to keep it in his mouth and saliva was swallowed as normal so if the effects came mainly because of absorption in the mouth or from being swallowed is somewhat unclear, but he reckons this small amount must have been absorbed rather quickly within the mouth before even starting swallowing.

    Luckily SWIM never got any puking nor even slightest nausea from any of the 2c's he tried so far (2c-t-2 - his favorite, 2c-e and 2c-i). He usually takes oral dosages of 25mg, sometimes two times within one day, and sometimes half and half mixed (for example 12.5mg 2c-t-2 along with 2c-e - something which was very interesting btw).

    god bless his amazing stomach, seems he was made for psychedelics (doesn't even puke on ayahuasca or peyote or lsa)
     
  9. May 2, 2012 #9
    PewterG

    PewterG Newbie

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    My rat, SWIM, has taken 2C-E rectally many times, usually using a syringe dissolved 5mgs/1ml water, and it is his favorite ROA for this chemical. He reports that initial alerts begin at T+0:15, and come smoothly to a climax at T+0:45-3:00 at 16mgs, with lingering influence, similar to taking it orally, still around well after the initial trip til at least T+7:00. The initial trip effects are reported as being prolonged at higher doses of 32 mgs, going well til T+9:00 with after effects affecting him well into the next day. He finds less anxiety, tremors, and "bottomless gut" feeling using this way, but one of his friends still experienced nausea at 32 mgs. He recommends it, but I don't do drugs.
     
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