Introduction to cytochrome P450

Cytochrome P450 creates enzymes "responsible for the metabolism of pharmaceuticals, foreign chemicals and pollutant; arachidonic acid metabolism and eicosanoid biosynthesis; cholesterol, sterol and bile acid biosynthesis; steroid synthesis and catabolism; vitamin Dᵌ synthesis and catabolism; retinoic acid hydroxylation", (Newbert DW, Russell DW) and many other enzymatic reactions essential for life processes. There are 27 known functional genes on cytochrome P450 and many pseudogenes which might play apart in the enzymatic processes of the genes (David R. Nelson et. all.)

Recreational drugs metabolized by CYP3A4

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CYP3A4 inhibitors

Benzodiazepines, LSD, MDMA, Marijuana, Cocaine, Amphetamines including Methamphetamines, Opiates and others have been identified (Dhananjay Pal, Ashim K Mitra)

CYP3A4 inducers

CYP2D6

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Genetic polymorphism

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Recreational drugs metabolized by CYP2D6

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CYP2D6 inhibitors

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CYP2D6 inducers

CYP2D6 is generally regarded as non-inducible. While some drugs such as rifampicin (rifampin) and dexamethasone were found to induce CYP2D6 in humans, this effect is not considered clinically significant. Many drugs and herbals were found to induce CYP2D6 in vitro (generally using human liver cell cultures or yeast-expressed CYP2D6), although this is generally not the case in humans.