Introduction to Duloxetine

Duloxetine (sold under the brand names Cymbalta, Ariclaim, Xeristar, Yentreve, Duzela) is a serotonin-norepinephrine reuptake inhibitor (SNRI) manufactured and marketed by Eli Lilly. It is effective for major depressive disorder and generalized anxiety disorder (GAD). Duloxetine failed the US approval for stress urinary incontinence amidst concerns over liver toxicity and suicidal events; however, it was approved for this indication in Europe, where it is recommended as an add-on medication in stress urinary incontinence instead of surgery.[1] It can also relieve the symptoms of painful peripheral neuropathy, particularly diabetic neuropathy,[2][3] and it is used to control the symptoms of fibromyalgia.

Using Duloxetine

Ways of Administration

Effects of Duloxetine

Side effects-Nausea, somnolence, insomnia, and dizziness are the main side effects, reported by about 10% to 20% of patient.
Effect of medication will ensue in 1-2 weeks and will subsequently optimally result in the reduction of depression symptoms.

Combinations with Duloxetine

The FDA has reported on life threatening drug interactions that may be possible when co-administered with any CNS stimulant, such as phentermine, diethylpropion, amphetamine, sibutramine, methylphenidate, methamphetamine, and cocaine leading to increased risk for serotonin syndrome

Different Uses for Duloxetine

Pharmacology of Duloxetine

Chemistry of Duloxetine

Column 1	Column 2
Systematic (IUPAC) name:	([gamma]S)-N-Methyl-[gamma]-(1-naphtalenoxy)-2-thiophenepropanamine
Synonyms:	(+)-(S)-N-methyl-[gamma]-(1-naphtyloxy)-2-thiophenepropylamine, (+)-N-methyl-3-(1-naphtalenyloxy)-3-(2-thienyl)propanamine, LY-248686; Ariclaim, Cymbalta, Yentreve (hydrochloride)
Molecular Formula:	C18H19NOS
Molar mass:	297.42 g/mol, 332.86 g/mol (hydrochloride)
CAS Registry Number:	116539-59-4, 136434-34-9 (hydrochloride)
Melting Point:	no data
Boiling Point:	no data
Flash Point:	no data
Solubility:	Hydrochloride slightly soluble in water
Additionnal data:	pKa in DMF/H2O 2:1 9.6
Notes:	Hydrochloride aspect : white to slightly brownish white solid

[1]

The Dangers of Duloxetine

Physical Health Risks

<Physical Problem 1 - Please Identify and Add Others As Necessary>

<Physical Problem 2 - Please Identify and Add Others As Necessary>

Overdose

Reported Deaths

Mental Health Risks

<Mental Health Risk 1 - Please Identify and Add Others As Necessary>

<Mental Health Risk 2 - Please Identify and Add Others As Necessary>

Side Effects

Addiction

Physical Addiction

Mental Addiction

Producing/Growing Duloxetine

Forms of Duloxetine

Legal Status of Duloxetine

United Nations

USA

EU

Other Countries

History of Duloxetine

More Duloxetine Sections

Duloxetine

References

[1]Merck Index, fifteenth edition (2013)