Experiences Methylenedioxypyrovalerone (MDPV) Experience Reports

Re: MDPV Experience Report(s)

it is the others' comfort levels that get stretched with the given monkey under MDPV. careful.

 

Re: MDPV Experience Report(s)

Those are dangerous assumptions to make, Nicaine. Chems can damage you through all kinds of mechanisms, and MDPV is new and unknown.
I feel that MDPV is not as friendly as other stims. It is too dose sensitive when it comes to catacholamines. With cocaine or speed, SWIM can push the euphoria way higher with repeated use, but with MDPV, hitting that magic 8mg creates a super unpleasant state of of extreme tachycardia (160-180bpm), sweating, dizziness, numbness of extremities, rapid and weak peripheral pulses with dropped beats, extreme overstimulation, shakes and confusion. This translates to SWIM as 'about to overdose and flop like a fish'. I had this happen twice now, and stopped it quickly with an atenolol and a light dose of a traquilizer I had put away for an emergency. I was fine after that, will all of MDPVs effects gone (SWIM always found propranolol to stop cocaine's high for SWIM too back when SWIM abused it, so go figure...).
Now for an well prepared idiot like SWIM, this is not a big deal. I could recognize and deal with the problem, but this could be deadly to someone else with a higher dose and nothing to control the symptoms with (ie - worse idiot who is not prepared). Now kratom and weed were on board both times and could be contributing factors, kratom as a stimulant and weed as an anticholinergic (increases heartrate), but I have never had this happen with the two latter alone. These reactions have prevented SWIM from pushing MDPV to 10 mg orally, and I am beginning to think that this chem has too short of a duration of effect and is too unpredictable for SWIM to push any further at all.
SWIM supposes that part of the fun is research, but not if it makes me feel like I am about to die.
And no, I am certain that these two episodes were not panic attacks. I was not nervous or had any of the normal thought patterns I have when these occur. In fact, I would not have dealt with them as rationally or quickly had they been.

 

Re: MDPV Experience Report(s)

The reason that I think it is dangerous to assume there are no long term problems with use of ANY chemical is that there are infinite mechanisms for such problems to occur. It could be that MDPV is really good at suppressing the bone marrow long term (like was found to be a side effect of many RX drugs), or perhaps it accumulates in neurons like mptp - > mpp+. My point is not that your assumptions about dopamine receptor depletion are wrong, but that these systems are infinitely more complicated than that, and the recent paultry short term evidence from a few subjective trials is useless as data for long term consequences, or even any meaningful charaterization of short term consequences. Even with FDA scrutiny, they pulled coxibs from the market after they were approved. Chloramphenical, a really useful antibiotic, got pulled from the human medicine market because it destroys the bone marrow of a small proportion of people by no known mechanism after being used for quite a while.
I'm not trying to screw with you, just point out something everyone here should acknowedge.
Tread lightly and don't be cocky.

 

Re: MDPV Experience Report(s)

In response to the rest of your thread, I think that kratom may be a contributing factor. Yohimbine is a alpha2 adrenergic antagonist, and as such will take the brakes off of any tachycardia by inhibiting activation of the alpha 2 which would normally decrease heart rate and blood pressure. This would predispose those with high levels of catecholamines to a more rapid heart rate.
Anyways, I am not pushing the dosage to see where it becomes toxic, but in the hope of finding a pleasant effect other than stimulation from this chemical. my trials have confirmed the fact that this is not available to SWIM without unpleasant side effects. Hence I will abort future trials and be happy that my monkeys used it up.
Each response is individual.
What is interesting is that even though I find few redeeming qualities in this molecule, it does have a stong addictive draw. Really reminds SWIM of some of the aspects of cocaine. While I was struggling with the side effects, SWIM still considered redosing as soon as my heartrate dropped. Bad sign.

 

Re: MDPV Experience Report(s)

Out of a senso of curiosity and a plain desire to see if it incresed potency, the thought of 'what's it like via IM?' crossed my mind. Full aseptic techniques were followed and 5mg was administered IM (in the upper thigh)...

I have a feeling that I've just opened Pandora's box with regard to MDPV. The euphoria was in the realm of 'fuck me, this is good', to the point that 10 mins after administration I was verging on omnipotent (well that's how I felt!) and my libido went through the roof in that whatever subject I considered, it was eventually linked to sex in one way or another. Then the 'oh fuck' effects kicked in... After about 2 hours the desire to redose was pretty damn strong, which I gave in to. After another 5mg I was a man with a plan (how I'd refer to the effects of something like methamphetamine on motivation & self confidence); I also could have easily, and with no feelings of embarrassment, performed a tour de force role as a porno star (would have had no problem with a display of public copulation, which I'd not consider when sober). After another 90 minutes I once again felt a strong desire to redose, but thought 'put distance between yourself & this drug so you can't redose' so went to a friends. While there the conversation kept returning to the subject of sex (but at leat I didn't redose).

Eventually, after about 4 hours I felt it was OK to go home; knowing the MDPV was nearby at hand did produce twinges to redose, but I did resist the urge, took a small amount of GBL and went to bed. I'm only glad my other half was working a late shift at work as I'm not certain that I wouldn't have tried to screw her to death!

Basically, dosing by this route pushes the euphoria, sex drive & urge to compulsively redose into the realms of cocaine (but without the acting like an arrogant twat that coke produces in me - which is why I avoid coke). Anybody indulging in administration by this route should be aware that both the good & the bad in MDPV increases by an order of magnitude; what IV would be like is something I don't even want to consider (I've never IVed anything and have no intention to ever do so), but if you are considering it, be warned you may start something you cannot later exert any control over (think IV coke administration, but with a clear head/thought patterns).

I thought long and hard as to whether to report this, but part of drug use is being informed and also taking responsibility for your actions, so in the interests of incresing knowledge about this substance I wen't with info dossemination, but you have been warned

 

Re: MDPV Experience Report(s)

Nicaine, please remember to set limits in advance.Before You takes more MDPV, make a promise to you's self that he will not use more than promised, and stick to that limit later in the future.
Remember what happened with You before, the propylhexedrine use that went out of control? Resist the temptation.
Also think about the fact that both MDPV and propylhexedrine's recreational use aren't well documented, and that not much about it is known yet.
you's lab animal can ofcourse use some substances once in a while, or do some "research" on it by administrating it to your lab animal, but he shurely doesn't want to become a lab animal used for discovering the substance's toxicity limits, let alone the LD50.

 

Re: MDPV Experience Report(s)

Or carcinogenesis and the organs affected...

 

Re: MDPV Experience Report(s)

From what I've heard from others & read about reports, smoking MDPV is not a good idea - it produces levels of compulsion near that of cocaine when taken by that route and is subject to a fair bit of pyrolysis (so you don't know what sort of heat degraded crap you're putting into your lungs). Basically a good way to see a lot of money disappear, behave like one of the fiends in the 1930 anti-cannabis films and end up feeling like warmed up shite with panic attacks.

From trying different routes other than snorting (don't snort anything due to dodgy sinuses) there is a marked difference between oral, rectal and IM. Oral is the least efficient; rectal is much more efficient, but IM is more efficient still(in terms of mgs required for same effect). I've never seen anything about metabolic fate in humans but I have a suspicion that MAO has an important role; gut MAO would have a small effect on the rectal route, but a much larger on on the oral one (and bog all on IM). I suppose an enzyme kinetics study with MAO & MDPV as the substrate would give the answer, but please don't use your body as a testing lab for this one as MDPV & a MAOI just feels like it has all the makings of a disaster (the sort involving hospitals & autopsies).


BTW Nicaine - rectal dosing has very little and IM no effects on the digestive system so I think any activity must be local to the region of the intestine containing the bulk of an MDPV dose (which would indicate that it might cause ulcers if repeatedly dosed, orally)

 

Re: MDPV Experience Report(s)

I found the sour stomach after each use, but also gets this from most other strong stims. SWIM pretreated with vitamins, nootropics, zantac (150mg every 12 hours for 2 doses) and anti-oxidants. SWIM also remembered to eat, which is not that hard with MDPV as opposed to other stimulants.
You should be really careful with combining MDPV with effexor. Effexor is a good antidepressant, but it is also the most addictive (physically) and side-effect ridden SSRI out there. With its reuptake inhibition of norepi as well as serotonin, taking something like MPDV could be really bad. It could also negate the effects, though since MDPV primarily tickled dopamine receptors, it should still work.
Be safe and SWIM hopes You gets well quickly. I used to end up in yous position all the time, but eventually my body just couldn't handle it anymore and SWIM learned to behave (most of the time...).

 

Re: MDPV Experience Report(s)

SWIM, who has no intention of trying propylhexedrine gets a sour stomach from too much MDPV alone. I do not get much in the way of depression from it, though. In fact, in smaller doses, it seems to be a good pick me up without a crash. I have found that dosing this in increments makes it much easier for SWIM to use (ie-2mg, followed by 1-2mg doses to effect). The hard part is stopping, since MDPV demands more MDPV. This is why SWIM swore off coke and amphetamines decades ago.