2-OXO PCM Deschloroketamine (also called DXE, DCK, or 2'-Oxo-PCM) is a chemical of the arylcyclohexylamine class which acts as a hallucinogenic dissociative anesthetic.
Introduction to 2-OXO PCM
This compound induces a state referred to as "dissociative anesthesia" when ingested and is therefore used as a recreational drug. DXE has recently become freely available through online research chemical vendors where it is being sold as a designer drug for research purposes only.
As DXE has been speculated to have antibacterial properties, its prolonged use could potentially pose a serious threat to one's health and immune system. This is a fairly common warning with this new drug. Perhaps someone can elaborate on this.
Author's note: While this is being touted as the newest replacement to MXE, don't be fooled. It is said to be more like ketamine with a long half-life that will leave you waking up slightly disassociated the next day. It's short acting, but long lasting. Doses are generally 30-50mg for a strong experience. It has been suggested that too much of this compound can create nasty health effects. Certainly not MXE.
Using 2-OXO PCM
Ways of Administration
Dose
Column 1 Column 2 Threshold mg Light mg Medium mg Strong mg Effects of 2-OXO PCM
2-OXO PCM combinations
Recreational drug combinations with 2-OXO PCM
No Recreational drug combinations with 2-OXO PCM have been added to this wiki yet.Dangerous interactions with 2-OXO PCM
No dangerous combinations with 2-OXO PCM have been added to this wiki yet.Medication interactions with 2-OXO PCM
No Medication combinations with 2-OXO PCM have been added to this wiki yet.Potentiators of 2-OXO PCM
No Potentiation combinations with 2-OXO PCM have been added to this wiki yet.Different Uses for 2-OXO PCM
Recreational use of 2-OXO PCM
Using 2-OXO PCM for ...
Using 2-OXO PCM for ...
Pharmacology of 2-OXO PCM
General
Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as 3-MeO-PCP, PCP and MXE. With this in mind, DXE is thought to act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “K-hole.”Targets, Enzymes, and Transporters
Targets
Enzymes
Transporters
Chemistry of 2-OXO PCM
Deschloroketamine, or 2-Phenyl-2-(methylamino)cyclohexanone, is classed as an arylcyclohexylamine drug. Ayrlcyclohexylamine drugs are named for their structures which include a cyclohexane ring bound to an aromatic ring along with an amine group. Descholoroketamine contains a phenyl ring bonded to a cyclohexane ring substituted with an oxo group (cyclohexanone). An amino methyl chain (-N-CH3) is bound to the adjacent alpha carbon (R2) of the cyclohexanone ring.
Descholoroketamine is a chiral molecule and is often produced as a racemate. Des- is a prefix used in chemistry to denote the absence of a functional group (in this case "chloro") hence deschloroketamine is named for lacking a chlorine substitution on its phenyl ring, which is found in ketamine.
*Rumor has it that this research chemical also contains trace amounts of ketamine. I can't cite this at the moment but am awaiting a NMR from the supplier.
Due to the lack of research regarding the substance, all discussion regarding the pharmacology of it is purely based on its structure and subjective effect similarities to other arylcyclohexylamine dissociatives such as 3-MeO-PCP, PCP and MXE. With this in mind, DXE is thought to act as an NMDA receptor antagonist. NMDA receptors allow for electrical signals to pass between neurons in the brain and spinal column; for the signals to pass, the receptor must be open. Dissociatives close the NMDA receptors by blocking them. This disconnection of neurons leads to loss of feeling, difficulty moving, and eventually this substance's equivalent of the “K-hole.”
Systematic(IUPAC) name: 2-(Methylamino)-2-phenylcyclohexanone Synonyms: 2-OXO PCM, Deschloroketamine, 2-Phenyl-2-(methylamino)cyclohexanone Molecular Formula: C13H17 Molar mass: 203.29 g/mol. CAS Registry Number: 4631-27-0 Melting Point: ** ℃+pressure if applicable Boiling Point: 331.3±42.0 °C at 760 mmHg Flash Point: 129.1±28.0 °C Solubility: **pharmacopeia style Additional data: Notes: Reagent test results of 2-OXO PCM
The Dangers of 2-OXO PCM
General Warnings
Side Effects and Interactions
Subjective effects
In terms of its subjective effects, this compound feels closer to that of ketamine than other compounds of the same class such as MXE and PCP. It is therefore a more suitable ketamine substitute than many other popular arylcyclohexylamines.
The effects listed below are based upon the subjective effects index and are personal experiences found throughout the web. The listed effects will rarely (if ever) occur all at once, but heavier dosages will increase the chances and are more likely to induce a full range of effects.
Physical Effects
Muscle relaxation
Tactile disconnection
Spontaneous tactile sensations
Tactile suppression
Physical autonomy
Motor control loss
Physical euphoria
Perception of decreased weight
Dizziness
Nausea
Visual sliding
Cognitive Effects
Depersonalization
Derealization
Consciousness disconnection
Memory suppression
Ego death
Thought deceleration
Immersion enhancement
Information processing suppression
Time distortion
Euphoria
Introspection
Déjà vu
Conceptual thinking
Compulsive redosing
Anxiety
Disinhibition
Amnesia
Creativity enhancement
Language suppression
Visual effects
Suppression
Visual disconnection - This eventually results in DXE's equivalent of the famous "k-hole" or, more specifically, holes, spaces and voids alongside of structures.
Visual acuity suppression
Double vision
Pattern recognition suppression
Frame rate suppression
Distortions
Perspective distortions
Environmental cubism
Environmental orbism
Scenery slicing
Geometry
Hallucinatory states
Internal hallucinations (autonomous entities; settings, sceneries, and landscapes; alterations in perspective and scenarios and plots)
Auditory effects
Suppression
Distortions
HallucinationsPotential Side Effects
Potential Drug Interactions
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Depressants - This combination potentiates the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it. Examples include 1,4-butanediol, 2-methyl-2-butanol, benzodiazepines, GHB, GBL, and opioids.Potential Food Interactions
Physical Health Risks
The toxicity and long-term health effects of recreational DXE use do not seem to have been studied in any scientific context and the exact toxic dosage is unknown. This is because DXE has very little history of human usage. Anecdotal evidence from people who have tried DXE within the community suggest that there do not seem to be any negative health effects attributed to simply trying this drug at low to moderate doses by itself and using it sparingly (but nothing can be completely guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
As DXE has been speculated to have antibacterial properties, its prolonged use could potentially pose a serious threat to one's health and immune system.
Urinary tract effects
In terms of its long-term health effects when used repeatedly and with excess for extended periods of time, DXE seems to exhibit almost identical bladder and urinary tract problems to those found within ketamine but to a lesser extent. This is because DXE is a little more potent than ketamine, meaning that less of the drug needs to be consumed. Symptoms of ketamine-induced cystitis can become extremely serious and can be described as:
Urinary frequency - Urinary frequency is the need to empty the bladder every few minutes.
Urinary urgency - This can be described as a sudden, compelling need to urinate.
Urinary pressure - This is experienced as a constant sensation of fullness in the bladder that is unrelieved by urination.
Pelvic and bladder pain - Pain can develop suddenly and severely, particularly as the bladder fills with urine.
Hematuria - Hematuria is visible blood in the urine.
Incontinence - This is the leakage of urine.
All of these, however, can easily be avoided by simply not using DXE on a daily or even weekly basis and manually limiting one's usage of the substance.
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
As with other NMDA receptor antagonists, the chronic use of DXE can be considered moderately addictive with a high potential for abuse and is capable of causing psychological dependence among certain users. When addiction has developed, cravings and withdrawal effects may occur if a person suddenly stops their usage.
Tolerance to many of the effects of DXE develops with prolonged and repeated use. This results in users having to administer increasingly large doses to achieve the same effects. After that, it takes about 3 - 7 days for the tolerance to be reduced to half and 1 - 2 weeks to be back at baseline (in the absence of further consumption). DXE presents cross-tolerance with all dissociatives, meaning that after the consumption of DXE all dissociatives will have a reduced effect.<Physical Problem 1 - Please Identify and Add Others As Necessary>
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Mental Health Risks
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Overdose
Reported Deaths
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