25B-NBOMe (NBOMe-2C-B) is a novel psychedelic research chemical and derivative of the phenethylamine 2C-B. It was first synthesized by Ralf Heim at the Free University of Berlin. It is a very potent compound with active doses in the mid-microgram range.
Introdution
25B-NBOMe is derived from the psychedelic phenethylamine 2C-B (4-bromo-2,5-dimethoxylphenethylamine) by substitution on the amine with a 2-methoxybenzyl (BOMe) group.
The drug is a very potent partial agonist of the 5HT-2A receptor (which belongs to the serotonin group of receptors) giving it its psychedelic effects.Ways of Administration
Insufflated
(dissolved in water):
Light - 50-200 µg (0.05 - 0.2 mg)
Mild - 200-350 µg (0.2 - 0.35 mg)
Strong - 350-800 µg (0.35 - 0.8 mg)
Very strong - 800 µg -1400 µg (0.8 - 1.4mg)
Insanity - 1400 µg+ (1.4 mg+)
Orally
Plugged
Sublingual
IM/IVEffects of 25B-NBOMe
Sublingual
Threshold - 100ug
Mild- 100-300
Strong - 350-700
Very strong - 700ug+
Duration:8-10hours
Come Up 1hour+
Plateau 3-4hours
(More information needed to verify dosage)
From liquid insufflation (strong dose):
Extreme patterning
Masses of vibrant coloring
Strong sound distortion - sounds leaking in and out of rooms and into the user
Very strong electric spasmodic body high
Complete ego loss
Loss of self
Loss of location, being, time, space etc
Inability to function at all normally
Slight nausea but passes quicklyCombinations with 25B-NBOMe
Beyond Anecdotal reports there exists no data on the combination of this drug with other agents.
Since 25B-NBOMe is a Research Chemical and very little is known about it, it is highly advised that combinations are not attempted with this substance.Different Uses for 25B-NBOMe
Pharmacology of 25B-NBOMe
25B-NBOMe is a potent and selective partial agonist at the 5-HT2A receptor. [1]
The Dangers of 25B-NBOMe
This is a very potent drug, the effects can peak rapidly and become uncomfortable and/or overpowering. A psychedelic crisis can occur.
These are the dangers common to all psychedelic drugs:
Accidental injury. When on a psychedelic drug, it is easier to accidentally injure yourself. Also because of the disorientating and potentially delusion inspiring nature of the experience, you could be lead to inflict harm on others or yourself. People have fallen off rooftops, run into traffic, attempted to throw people off rooftops as 'sacrifices', drowned, and so on. The best way of protecting against this is to have a friend with you who is sober to look after you and handle any negative situation that might arise.
Bad trips. A bad trip is a negative psychedelic experience. It can range from a mildly negative feeling of anxiety/discomfort, to full-blown psychosis. Bad trips usually ruin a psychedelic experience for the tripper and everyone else. Most bad trips are manageable, just very uncomfortable and difficult. Some are extreme and unmanageable though. It's not uncommon for a bad trip to result in lingering psychological issues. Usually just a few days of negative emotions and anxiety. Sometimes, however, a week or so of serious anxiety, destabilized mental state and impaired functioning is possible. On very rare occasions, a month or two of severely diminished functioning, traumatized mental state, depression & crippling anxiety can occur. More information on bad trips can be found here. The best way of avoiding a bad trip is having the correct set and setting.
Permanent psychosis. Psychedelics are believed by researchers not to cause permanent psychosis, however they could trigger a latent mental illness in someone who was already predisposed to it, or make existing mental illnesses worse. If there is a history of mental illness in your family, you are more likely to be predisposed. Everyone is at some risk, however.
PTSD, anxiety disorder, depression & depersonalization. There are anecdotal reports of the trauma inflicted by some bad trips leading to depression and anxiety which while usually temporary, could potentially develop into lasting disorders. While no different to the potential of any traumatic event to cause lasting disorders, nonetheless this is a danger of psychedelic drug use.
Legal Status of 25B-NBOMe
United Nations
UncontrolledUSA
Uncontrolled at Federal and State level, though arguably may contravene the Federal Analog Act under certain circumstances given its structural and functional similarity to controlled substance 2C-B.EU
LegalUnited Kingdom
25B-NBOMe is uncontrolled in the United Kingdom, as N-benzyl derivatives of phenethylamine are not covered by the phenethylamine derivatives clause of the Misuse of Drugs Act 1971.Other Countries
History of 25B-NBOMe
25B-NBOMe was first synthesized by Ralf Heim. [2]
More 25B-NBOMe sections
25B-NBOMe(2C-B-NBOMe) Drug Info
References
- ^Ettrup, A.; Hansen, M.; Santini, M. A.; Paine, J.; Gillings, N.; Palner, M.; Lehel, S.; Herth, M. M. et al. (2010). "Radiosynthesis and in vivo evaluation of a series of substituted 11C-phenethylamines as 5-HT2A agonist PET tracers". European Journal of Nuclear Medicine and Molecular Imaging
- ^Ralf Heim PhD. Synthese und Pharmakologie potenter 5-HT2A-Rezeptoragonisten mit N-2-Methoxybenzyl-Partialstruktur. Entwicklung eines neuen Struktur-Wirkungskonzepts. (German)