2C-D (4-methyl-2,5-dimethoxyphenethylamine) is a psychedelic phenethylamine first described by chemist Alexander Shulgin in his book PiHKAL: A Chemical Love Story. 2C-D is usually taken orally or insufflated with a typical dose in the range of 10-40mg. 2C-D is reported to be far less intensely hallucinogenic and entactogenic than other phenethylamines. It has been explored as a potential nootropic at very low doses.

Introduction to 2C-D

[​IMG]2C-D was initially synthesised in 1970 by a team of scientists at the Texas Research Institute of Mental Sciences. Its activity in humans however, was not discovered until Alexander Shulgin began experimenting with the compound in his personal laboratory, where it was determined that 2C-D was in fact a moderately strong psychedelic hallucinogen. Mr.Shulgin himself described 2C-D as being "pharmacological tofu".

Using 2C-D

2C-D oral dosage chart...
Column 1 Column 2
Threshold 1-4 mg
Light 4-15 mg
Moderate 15-50 mg
Strong 50-100 mg

Ways of administration

2C-D is commonly administered through oral consumption, providing a greater range of effects as the result of an abundant amount of 5-HT serotonin receptors which line the walls of the gastrointestinal tract. 2C-D has also been proven to be effective through intranasal insufflation, though this route of administration may prove to be extremely painful.

Effects of 2C-D


  • Stimulation
  • Euphoria
  • Cognitive enhancements
  • Feelings of empathy and love
  • Sensory enhancements
  • Increased talkativeness
  • Feelings of joy and laughter
  • Sense of mental clarity


  • Change in consciousness
  • Shift in perception
  • Open and closed eye visual hallucinations
  • Auditory distortions
  • Changes in perception of time
  • Increased sexual arousal
  • Confusion


Combinations with 2C-D

Different Uses for 2C-D

Pharmacology of 2C-D

2C-D acts as a selective agonist for the 5-HT serotonin receptors with pEC50 values of 5.09 for 5-HT2A and 4.73 for 5-HT2C.

Chemistry of 2C-D

Column 1 Column 2
Systematic(IUPAC) name: 1-(2,5-Dimethoxy-4-methylphenyl)-2-aminoethane
Synonyms: 2C-D, 2C-M
Molecular Formula: C11H17NO2, C11H17NO2.HCl (hydrochloride)
Molar mass: 195.26 g/mol, 231.72 g/mol (hydrochloride) [1]
CAS Registry Number: 24333-19-5
Melting Point: 213-214 °C (hydrochloride)
Boiling Point:
Flash Point:

Reagent test results of 2C-D

Reagent color produced picture video
H2SO4 No reaction[1] link -
Marquis Clear yellow[1] - -
Mecke Dark olive[1] - -
Cobalt thiocyanate Pink (no reaction)[1] - -

The dangers of 2C-D

There are several dangers associated with 2C-D that one should be aware of prior to administering the compound.
  • 2C-D is a research chemical, thus its short-term and long-term effects have yet to be fully determined through formal studies.
  • 2C-D acts as a central nervous stimulant, thus users whom have a known physical illness should avoid this compound as it may potentiate such symptoms resulting in an undesirable and possibly dangerous reaction.
These are the dangers common to all psychedelic drugs:

Accidental injury.
When on a psychedelic drug, it is easier to accidentally injure yourself. Also because of the disorientating and potentially delusion inspiring nature of the experience, you could be lead to inflict harm on others or yourself. People have fallen off rooftops, run into traffic, attempted to throw people off rooftops as 'sacrifices', drowned, and so on. The best way of protecting against this is to have a friend with you who is sober to look after you and handle any negative situation that might arise.

Bad trips. A bad trip is a negative psychedelic experience. It can range from a mildly negative feeling of anxiety/discomfort, to full-blown psychosis. Bad trips usually ruin a psychedelic experience for the tripper and everyone else. Most bad trips are manageable, just very uncomfortable and difficult. Some are extreme and unmanageable though. It's not uncommon for a bad trip to result in lingering psychological issues. Usually just a few days of negative emotions and anxiety. Sometimes, however, a week or so of serious anxiety, destabilized mental state and impaired functioning is possible. On very rare occasions, a month or two of severely diminished functioning, traumatized mental state, depression & crippling anxiety can occur. More information on bad trips can be found here. The best way of avoiding a bad trip is having the correct set and setting.

Permanent psychosis. Psychedelics are believed by researchers not to cause permanent psychosis, however they could trigger a latent mental illness in someone who was already predisposed to it, or make existing mental illnesses worse. If there is a history of mental illness in your family, you are more likely to be predisposed. Everyone is at some risk, however.

PTSD, anxiety disorder, depression & depersonalization. There are anecdotal reports of the trauma inflicted by some bad trips leading to depression and anxiety which while usually temporary, could potentially develop into lasting disorders. While no different to the potential of any traumatic event to cause lasting disorders, nonetheless this is a danger of psychedelic drug use.

Producing 2C-D

Forms of 2C-D

2C-D is most commonly found in either a hydrochloride or hydrobromide salt.

2C-D Hydrochloride Salt

United Nations


As of July 9th, 2012, 2C-D is considered to be a schedule I substance in the United States, covered under the Food and Drug Administrations "Safety and Innovation Act".


United Kingdom

2C-D is a class A controlled substance as it is covered by the phenethylamine derivatives clause of the Misuse of Drugs Act 1971.

Other Countries


As of December 2008, 2C-D is considered to be a controlled substance in Israel.


As of March 1st, 2005, 2C-D is considered to be a controlled substance in Sweden.

History of 2C-D

More 2C-D Sections

The latest 2C-D threads


  1. ^ a b c dhttp://www.reagent-base.net/reagents-table/

[1] Calculated from Atomic Weights of the Elements, 2007

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