4-HO-MET is a psychedelic tryptamine that was first synthesized by Alexander Shulgin, and discussed in his book TIHKAL. It is a structural and functional analog of both MET and psilocin. The effects can include heavy distortion of colors, morphing, as well as sound distortions. Very little is known about the pharmacological and toxicological properties of this substance.

Introduction to 4-HO-MET

4-HO-MET belonging to the class of Tryptamines, is a structural analogue of psilocin, it is said to have effects almost identical to psilocin according to Alexander Shulgin who first synthesized the compound. 4-HO-MET like many other psychedelic substances acts upon the 5HT2A Serotonin receptors.

Using 4-HO-MET

Ways of administration

4-HO-MET can be either be ingested orally or insufflated. Orally it tends to have a greater effect, with the experience lasting longer then a comparative dose via insufflation. The more preferred method of administration is oral consumption.


Orally 4-HO-MET can last anywhere from 4 to 6 hours, while insufflation lasts anywhere from 2 to 4 hours, while insufflation may cause a more intense experience it often lacks the essential values associated with a psychedelic experience sometimes leaving the user unprepared for the upcoming events.

Threshold <5mg
Low 5-10mg
Moderate 10-16mg
High 16-25mg
Very High 25mg>

Threshold <4mg
Low 4-9mg
Moderate 9-15mg
High 15-20mg
Very High 20mg>

Effects of 4-HO-MET

Color enhancement
Increase in mood
Abstract thinking
Enhanced tactile sensations
Appreciation of music
Cartoon like visuals

Shift in consciousness
Closed and open eye visual hallucinations
Pupil Dilation
Distortion in perception of time
Slight increase in heart rate
Slight increase in blood pressure

Jaw Tension

Combinations with 4-HO-MET

Different Uses for 4-HO-MET

Pharmacology of 4-HO-MET

Chemistry of 4-HO-MET

CAS Number: 778872-41-4
IUPAC Name: 3-(2-(ethyl(methyl)amino)ethyl)-1H-indol-4-ol
Formula: C13H18N2O
Molecular Weight: 218.29482
Density: 1.15 g/cm3
Boiling Point: 403.051 °C at 760 mmHg
Flash Point: 197.559 °C

The dangers of 4-HO-MET

These are the dangers common to all psychedelic drugs:

Accidental injury.
When on a psychedelic drug, it is easier to accidentally injure yourself. Also because of the disorientating and potentially delusion inspiring nature of the experience, you could be lead to inflict harm on others or yourself. People have fallen off rooftops, run into traffic, attempted to throw people off rooftops as 'sacrifices', drowned, and so on. The best way of protecting against this is to have a friend with you who is sober to look after you and handle any negative situation that might arise.

Bad trips. A bad trip is a negative psychedelic experience. It can range from a mildly negative feeling of anxiety/discomfort, to full-blown psychosis. Bad trips usually ruin a psychedelic experience for the tripper and everyone else. Most bad trips are manageable, just very uncomfortable and difficult. Some are extreme and unmanageable though. It's not uncommon for a bad trip to result in lingering psychological issues. Usually just a few days of negative emotions and anxiety. Sometimes, however, a week or so of serious anxiety, destabilized mental state and impaired functioning is possible. On very rare occasions, a month or two of severely diminished functioning, traumatized mental state, depression & crippling anxiety can occur. More information on bad trips can be found here. The best way of avoiding a bad trip is having the correct set and setting.

Permanent psychosis. Psychedelics are believed by researchers not to cause permanent psychosis, however they could trigger a latent mental illness in someone who was already predisposed to it, or make existing mental illnesses worse. If there is a history of mental illness in your family, you are more likely to be predisposed. Everyone is at some risk, however.

PTSD, anxiety disorder, depression & depersonalization. There are anecdotal reports of the trauma inflicted by some bad trips leading to depression and anxiety which while usually temporary, could potentially develop into lasting disorders. While no different to the potential of any traumatic event to cause lasting disorders, nonetheless this is a danger of psychedelic drug use.

Producing 4-HO-MET

Forms of 4-HO-MET


4-HO-MET is available in both HCL and Fumarate, Fumarate is more common due to its longer shelf life as 4-HO-MET tends to rapidly oxidize and degrade especially in HCL form. The Fumaric version of 4-HO-MET has a higher stability then the HCL version, however the HCL version is slightly more potent by mass then the Fumaric.

Freshly synthesized 4-HO-MET initially appears as a white powder, over time and improper storage it will begin to oxidize and degrade which in turn will cause a change in color. It is speculated that while the compound does show visible signs of degradation there is very little if any loss of potency.

United Nations

While 4-HO-MET is not scheduled in the United States it may be considered an analog of Psilocin thus falling under the Federal Analog Act.



Other Countries

4-HO-MET has been classified as a controlled substance in Sweden since May 1, 2012.

Popularity of 4-HO-MET

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