Clomipramine (Anafranil) is in a group of medications called tricyclic antidepressants. The actual neurochemical mechanism is unknown, but its ability to inhibit the reuptake of serotonin (5-HT) is thought to be important in the treatment of obsessive and compulsive behaviors.
Introduction to Clomipramine
Clomipramine is used as an antidepressant and antiobsessional agent. It has also a veterinary use to treat canine separation anxiety.
Chemistry of Clomipramine
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Column 1 Column 2 Systematic(IUPAC) name: 3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine Synonyms: 3-chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine, 5-([gamma]-dimethylaminopropyl)-3-chloroiminodibenzyl, chlorimipramine, G 34586; adrafanil, clomicalm (hydrochloride) Molecular Formula: C19H23ClN2 Molar mass: 314.86 g/mol, 351.32 g/mol (hydrochloride) CAS Registry Number: 303-49-1, 17321-77-6 (hydrochloride) Melting Point: 189-190°C(crystd from acetone-ether), also reported 191.5-192°C(crystd from acetone) (hydrochloride) Boiling Point: 160-170°C @ 0.3 mmHg Flash Point: no data Solubility: Freely soluble in water, methanol, methylene chloride. Practically insoluble in ethyl ether, hexane Additionnal data: none Notes: crystals from acetone-ether/methanol ether or acetone
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