JWH-250 is a synthetic cannabinoid that binds CB1 and CB2 receptors. It is more selective for the CB1 receptor and produces effects consistent with naturally occuring cannabinoids.
Using JWH-250
Effects of JWH-250
JWH-250 has been described as slightly more potent, though shorter lasting than JWH-018.
Routes of Administration
Topical
Internal
Parenteral
Tolerance
JWH-018 exhibits a traditional tachyphylactic response in repeated dosing, with a notable decrease in both effect and duration after 3 days of chronic dosing [1]. JWH-250 can likely produce this same effect. This tolerance is likely the result of CB1/2 receptor downregulation, similar to the tolerance developed from ∆-9-THC or Cannabis administration as discussed here under the Tolerance heading and in much greater detail in a dedicated thread here: Cannabis and Cannabinoid Tolerance.
Pharmacology and Pharmacokinetics of JWH-250
Enzyme Inhibition by JWH-250
Cannabinoid Receptor (CB1/CB2) Binding of JWH-250
The Ki (binding affinity) values for primary cannabinoid (CB1/CB2) receptors are Ki = 11 and 33 nM, respectively, showing a greater selectivity for the CB1 receptor over the CB2 receptor. The Ki ratio for the receptors is thus CB1:CB2, 0.33 [2].
Molecular Pharmacology of JWH-250
Metabolism of JWH-250
Half-Life of JWH-250
Forms of JWH-250
Pure JWH-250
Chemical characteristics
Column 1 Column 2 Systematic (IUPAC) name: 2-(2-methoxyphenyl)-1-(1-pentyl-1H-indol-3-yl)ethanone Synonyms: 1-pentyl-3-(2-methoxyphenylacetyl)indole Molecular Formula: C22H25NO2 Molar mass: 335.44 g/mol [2] CAS Registry Number: 864445-43-2 Melting Point: 82.6 °C [1] Boiling Point: Flash Point: no data Solubility: ~2 mg/ml (ethanol), ~20 mg/ml (dimethylsulfoxide); ~25 mg/ml (dimethylformamide) [3] Additionnal data: Notes: aspect : pink powder [1] Appearance
JWH-250 can appear is a white, yellow, or light pink powder depending on purity.
More JWH-250 sections
JWH-250 Info- Read & discuss information regarding JWH-250
JWH-250 Experiences- Post & read experiences with JWH-250
JWH-250 File archive entries- Upload & read research & articles about JWH-250.
JWH-250 Image gallery- Post & view pictures of JWH-250.The latest JWH-250 threads
References
- ^Mouse99. JWH-018 Repeat Rat Toxicity. Raw data. Netherlands. 18 Dec. 2008.
- ^Huffman JW, Szklennik PV, Almond A, Bushell K, Selley DE, He H, Cassidy MP, Wiley JL et al. (2005). "1-Pentyl-3-phenylacetylindoles, a new class of cannabimimetic indoles". Bioorganic & medicinal chemistry letters 15 (18): 4110–3
[1] JWH-250 monograph
[2] Calculated from Atomic Weights of the Elements, 2007
[3] Cayman Chemical Company. Material Satefy Data Sheet- JWH-250. Brochure. Ann Arbor, MI: Author, 2009.