Introduction to Dimethocaine
Dimethocaine also known as Larocaine or DMC is a cocaine analogue and local anesthetic and is currently classified as a research chemical. Like other stimulants, Dimethocaine purportedly produces euphoria and a heightened sense of well-being, though users report much milder effects compared to those of cocaine. [1] [2] An initial study placed its potency between 47%-70% of cocaine [3], though more recent anecdotal reports have questioned that figure. A 2005 study performed with rhesus monkeys found that 1 mg/kg/infusion of Dimethocaine was needed to produce the same results a .1 mg/kg/infusion of cocaine. [4]
Using Dimethocaine
Ways of Administration
The most common method of administration is through insufflation, though it appears that any route of administration is available for this RC, based on a wide variety of user reports. [5][6] [7]
A typical dose range if taken orally/nasally is from 50mg to 200 mg, which a slight decrease with IV use. [8]Effects of Dimethocaine
Good
Euphoria, increased sense of well-being, heightened awareness, appetite suppression
Bad
Vascoconstriction, heightened blood pressure, sweating, tachycardia, heart function impairment, respiratory difficulties, insomnia
Due to its recent entry as a cocaine substitute, long-term effects have not been studiedCombinations with Dimethocaine
Various anecdotal reports suggest users have combined Dimethocaine with every possible legal, illegal, or quasi-legal substance. [9] One user reported a mixture of heroin and Dimethocaine (similar to classic speedball. His results found that Dimethocaine was overpowered by the heroin. [10] Due to the risks of cardio-vascular impairment, combinations of Dimethocaine and other stimulant products should be avoided.Different Uses for Dimethocaine
Dimethocaine was produce by Roche Pharmaceuticals as a local anesthetic under the name Larocaine. By the end of the 1940's, it had fallen out of favor.
[11]
Pharmacology of Dimethocaine
One unique feature in Dimethocaine's structure is the p-NH2 pharmacophore which is somewhat rare for a dopamine reuptake inhibitor.
Minimum lethal dose (mg/kg) [1] :
Mice : 300 subcutaneously, 40 intravenously
Rabbit : 150 subcutaneously, 15 intravenously
Chemistry of Dimethocaine
Unlike cocaine, Dimethocaine lacks a tropane ring. Synthesis would be possible through condensing 4-aminobenzoic acid ethyl ester with diethylamino-t-butanol. [12]
[1]
Column 1 Column 2 Systematic (IUPAC) name: (3-diethylamino-2,2-dimethylpropyl)-4-aminobenzoate Synonyms: 2-[(diethylamino)methyl]-2-methyl-1-propanol 1-(4-aminobenzoate), 3-(diethylamino)-2,2-dimethyl-1-propanol p-aminobenzoate, 3-diethylamino-2,2-dimethylpropyl p-aminobenzoate, 1-aminobenzoyl-2,2-dimethyl-3-diethylaminopropanol, p-aminobenzoate of dimethylaminoneopentyl alcohol, Larocaine Molecular Formula: C16H26N2O2, C16H26N2O2.HCl (hydrochloride) Molar mass: 278.40 g/mol, 314.85 g/mol (hydrochloride) CAS Registry Number: 94-15-5, 533-63-9 (hydrochloride) Melting Point: 196-197°C (hydrochloride) Boiling Point: no data Flash Point: no data Solubility: Hydrochloride 1 part dissolves in 3 parts water (20°C), 10 parts cold alcohol, 5 parts boiling alcohol; practically insoluble in ether, oils, fats Additionnal data: none Notes: Hydrochloride aspect : minute crystals or powder, sometimes fine leaflets; bitter taste; aqueous solution may be sterilized at 105°C for 10 minutes
The Dangers of Dimethocaine
Like cocaine, Dimethocaine can place a heavy strain on the cardiovascular systems with the potential of tachycardia for those who continuously redose. Additional reports of respiratory arrest have been noted. [13]Though its potency is less than that of cocaine, Dimethocaine has been reported to be cocaine's equal in its effect on the cardio respiratory system due to its anesthetic effects. Studies performed with lab mice also suggest that Dimethocaine impairs short-term memory and cognitive function. [14]
Legal Status of Dimethocaine
USA
EU
UK
Other Countries
Dimethocaine is unscheduled in Canada. [15]
References
- ^http://www.drugs-forum.com/forum/group.php?do=discuss&group=&discussionid=1027
- ^https://www.erowid.org/experiences/exp.php?ID=82701
- ^Woodward JJ, Compton DM, Balster RL, Martin BR. In vitro and in vivo effects of cocaine and selected local anesthetics on the dopamine transporter. Eur J Pharmacol. 1995 Apr 13;277(1):7-13. PubMed PMID: 7635175.
- ^Wilcox, KM; Kimmel, HL; Lindsey, KP; Votaw, JR; Goodman, MM; Howell, LL (2005). "In vivo comparison of the reinforcing and dopamine transporter effects of local anesthetics in rhesus monkeys.". Synapse 58 (4): 220–8. doi:10.1002/syn.20199. PMID 16206183.
- ^https://www.erowid.org/experiences/exp.php?ID=82701
- ^https://www.erowid.org/experiences/exp.php?ID=83031
- ^http://www.drugs-forum.com/threads/91881
- ^https://sites.google.com/site/dimethocaine02/dimethocaine
- ^http://www.drugs-forum.com/threads/91881
- ^https://www.erowid.org/experiences/exp.php?ID=83031
- ^A method for topical anesthesia by nebulization of local anesthetics
MILLER JB, MANN FF, ABRAMSON HA.
CHEST
. 1949;16(4):408-419.
- ^An overview of new psychoactive substances and the outlets supplying them
- ^http://www.drugs-forum.com/threads/91881
- ^BLATT, S.L. and TAKAHASHI, R.N.. Memory-impairing effects of local anesthetics in an elevated plus-maze test in mice. Braz J Med Biol Res [online]. 1998, vol.31, n.4 [cited 2012-08-12], pp. 555-559 . Available from: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X1998000400013&lng=en&nrm=iso>. ISSN 1414-431X. http://dx.doi.org/10.1590/S0100-879X1998000400013.
- ^http://isomerdesign.com/Cdsa/ocsStatus.php
- ^Brandt, S. D.; Sumnall, H. R.; Measham, F.; Cole, J. (2010). "Second generation mephedrone. The confusing case of NRG-1". BMJ 341: c3564. doi:10.1136/bmj.c3564. PMID 20605894
[1]Merck Index, fifteenth edition (2013)