Drug information Methylenedioxypyrovalerone (MDPV) Drug Info

I think you can call it a Pyrrolidin Ketone, or PK. I tend to trust f&b on these things, as he seems to sort of specialize in SAR. Of course no one really knows, unless the compounds are made and tested.

 

not about not trusting F&B and his vast array of knowledge in this area... just saying that they have to be active somehow so what would their nature be? its obvious that the potency should be way way up from the parent compounds...

:joint:

 

The alpha propyl group prevents the molecule interacting with the 5HT2a receptor as anything bigger tham a methyl group is too big to let the molecule 'get in the right place' (it's a region of steric hinderance, as Nichols calls it).

MDPV is more potent as a dopamine reuptake inhibitor, but that's very different from any activity at the 5HT2a (or any serotonogic) receptor. There's a lengthy post I made on another forum entitled 'Acid, dragonflies & the 5HT2a receptor' (, if that's allowed) that explains why anything bigger than an alpha methyl group removes all psychedelic activity, along with other aspects of SAR with respect to the 5HT2a receptor (ie psychedelic activity)

 

we should all take a moment to appreciate the fact that the member who posted above me knows as much as anyone else in this field. kudos f&b. what would we ever do without you?

:joint: :smoker:

 

so what then of my theoretical compounds fastandbulbous? how would they act as it seems they should certainly be active. just different types of stimulants with insane potency or something more(less?).

by the way is your name from the fastandbulbous from rocket pierre?

 

Nah, it's from the babbling bits from 'Trout Mask Replica' (Captain Beefheart)!

Not really sure about the substituted phenylpentanones; the 3,4-methylenedioxy might end up being the most potent because it has oxygen atoms at the same position on the ring as dopamine, so is more likely to interact with the DAT (dopamine transporter responsible for uptake). They might be decent reuptake inhibitors, but the chances of any other activity seem very slight.


Without me you'd get less of the sarcastic fat hippie comments in some threads!


Oh, BTW I tried recrystallizing some from ethanol & making up a sterile soln with a micron filter for the purpose of trying a parenteral dose. 2.5mg IM produced an amazing libido stimulating effect (which is much more noticable as you get older!) that lasted a few hours & was on a par with the best that amphetamine could offer in that field; it was still an incredibly clear thinking state of mind. A few days later I tried the same along with a small amount of cannabis and sex was like being 18/19 years old again. Wouldn't recommend anything over 4-5mg by this route though

 

it is a very fine line between clearheadedness and insanity with this compound. please exercise much caution as:

a. very easy to overdose, which may produce a long lasting panic attack.
b. hygroscopic. material exposed to air in the scoop on the milligram scale gained weight right before the observer's eyes. thus, it clumps forming very dense chunks. do not eyeball.
c. it has lasting conseqences on your cognitive function and emotional stability.

 

I wish I could read this article.

 

What lasting consequences to cognitive function and emotional stability are you referring to, nanobrain ? Does it make you manic ? For how long (ie - a la post MDMA crankiness ?)

Snapper

 

Nostawk, PM me your email addy, i'll send you the article.

thadj

 

^^since it fairly obviates the need for sleep or nutrition, loss of associative memory (storage and recall) has been reported by some after a 'run', together with auditory hallucinations of a particularly catlike-mewling nature.

while others complain of comedowns lasting months from one-time admin, yet covet the microgram crumbs others claim not to note any effects, but they are deluded as motorics are exaggerated. both groups appear to covet the remaining micrograms. no dirty carpet surface was safe from the fienders fine eyetoothcombs.

i aslo feel it has an effect on some cerebellum / spatial coordination / balance-related structures as there is noted peripheral jerkiness to movements and a lesser perceived but still noted decrease in hand-eye coordination, which, if left unmitigated, with prolonged use becomes rather severe.

this raises flags of caution in re destruction of dopaminergic neurons (early Parkinsonism) probably in the substantia nigra - how lasting these consequences remains to be seen.

the potency of these compounds is high and the targeting of the molecules so specific that unless the keys are perfectly reflective of particular neuronal subsets topology, even trace impurities could prove active and neurologically damaging.

as for permanent reorientation of the reward circuitry value systems, it appearsto be self-evident among a group of subjects.

i am sure the emergency room cases will start showing up.
exercise caution with your animals.

 

so what im hearing is that there is basically nothing good about this except the rush... ok so then lets start a forum pool... the over under for scheduling is set at 9 months. any takers?

:joint:

 

I haven't any experience with it but if he were to guess it would be far more than nine months to scheduling. BZP (not making any comparisons here) made it's rounds as a stimulant for some years before it's scheduling.

The long/difficult 'come-downs' SWIM's read in this here thread don't make it sound too appealing...

 

Nano, sounds like a description for the China White of the entactogenic-stimulant family. If you recall what that designer-drug of the fentanyl-family was found to do. Thanks for sounding the warning bell. Do keep us informed on this.

 

BZP is a relatively safe compound and has a track record, having been available around 8+ years and with documented human trials.
MDPV is seeming to not be safe at all, or at least suspect. There are no studies documenting side effects to speak of and only anecdotal trials. Many of the reports make this stuff sound like crack with a worse hangover. So far not very confidence inspiring. Maybe if SWIU are lucky it will go away. As I understand it it is hard to make? Perhaps those distributing this should take a hint and give it up.

Snapper

 

well, the adage that if the only tool you have is a hammer, every job becomes a nail seems to apply.

yet as Confuse-u-is (as different from that other guy) said, one must know his true name, and the name of the pentan is not hammer - so perhaps its job is not that of a nail pounder...

 

This is odd - I find it actually inproves hand/eye coordination very very much so.. my hands are VERY steady, and -- well, as nanobrain would know, its the same kind of steadyness, accuracy, fluidity of motion that a low dose of DMT gives, took a little earlier and my hands are visibilly not shaking at all (well ok, if i look hard enough its there just WAY less than sober if you know what i mean).

Moving around and doing things my coordination is greatly improved - all similar to low dose DMT - but unlike DMT, the brain is "cranked up"/overclocked to do these things.. where with DMT, (i'd expect only nanobrain to understand what i'm talking about with DMT ahem / experienced) the brain makes up for the increase in coordination/fluidity (higher "framerate" vision) by reducing energy load on other parts of the brain like certain visual details (a little more basic geometry, more is discarded in favour of increased coord/fluidity/etc).

So nanobrain, you have mixed DMT and MDPV.. how is this? very curious.. Does DMT kill some of the side effects you experience with MDPV?

 

what gives with that complete off topic post about DMT?

hey, forgive me if im wrong, but arent you that Research Chemical vendor wannabe guy who was spamming everywun about DOC and than passed some DOI as 2ci? Hey didnt you get like raided or something, hows that thing going? Did LE made you snitch? How come youre free?

 

MDPV Frequent Use

I’m following the Discussion for some Time now, as one of my frogs is using MDPV for several weeks daily now. Therefore I’d like to make some Comments from observations of them...

I completely agree with Nanobrain on these points, and I don’t doubt that his later posts concerning MDPV are at least a realistic assessment.

Here is the report from one of my top racing fromgs (they're not the fasted but have an amazing leap...an unheard of knack for the english language.

 

^ Positive rep left for the informative post, but please peruse the rules regarding self-incrimination.